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The role of P450IIE1 protein and mRNA expression in determining adipose tissue skatole level

  • E. Doran (a1), F. Whittington (a2), J.D. Wood (a2) and J.D. McGivan (a1)

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High concentrations of skatole in adipose tissue are a major factor in boar taint - the offensive odor and taste in cooked pork from some intact male pigs. Skatole is produced by bacterial fermentation of tryptophan in the large intestine, absorbed into the blood and transported into the liver, where it can be metabolised via the cytochrome P450 system. One reason for high skatole levels in pig adipose tissues could be low expression of hepatic cytochrome P450IIE1 in liver and hence a reduced rate of skatole clearance, but no correlation was found between the rate of skatole metabolism and the P450IIE1 content of isolated liver microsomes. The present study re-investigates the relationship between backfat skatole, liver P450IIE1 expression and the rate of microsomal skatole metabolism in two breeds of pigs.

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The role of P450IIE1 protein and mRNA expression in determining adipose tissue skatole level

  • E. Doran (a1), F. Whittington (a2), J.D. Wood (a2) and J.D. McGivan (a1)

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