Skip to main content Accessibility help
×
Home

Prediction of prion protein genotypes and study of association with lamb performance traits of Suffolk sheep

  • R. M. Sawalha (a1), B. Villanueva (a1), S. Brotherstone (a2) and R. M. Lewis (a3)

Extract

The relative susceptibility to classical scrapie is mainly determined by polymorphisms at codons 136, 154 and 171 of the prion protein (PrP) gene (Hunter et al., 1996). Five haplotypes, defined by the combination of variants at these three codons are commonly found in sheep; scrapie eradication programmes in several countries are based on changing their frequencies. In Suffolk sheep, one codon shows variation, with the R allele associated with resistance and the Q allele associated with susceptibility. Genotyping costs may be reduced by utilizing information from relatives to infer the genotypes of other relatives. The objectives of this study were to determine the effectiveness of predicting PrP genotypes using information from relatives and to investigate the association of PrP gene with lamb performance traits in Suffolk sheep.

Copyright

Corresponding author

References

Hide All
Hunter, N, Foster, JD, Goldmann, W, Stear, MJ, Hope, J, Bostock, C. 1996. Arch Virol 141: 809–824.
Kerr, and Kinghorn, . 1996. J. Anim. Breed. Genet. 113: 457–469.

Prediction of prion protein genotypes and study of association with lamb performance traits of Suffolk sheep

  • R. M. Sawalha (a1), B. Villanueva (a1), S. Brotherstone (a2) and R. M. Lewis (a3)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed