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Evidence for a new form of dominant negative imprinting at the ovine callipyge locus

Published online by Cambridge University Press:  05 November 2021

N.E. Cockett ,
S.P. Jackson ,
T.L. Shay ,
F. Farnir ,
S. Berghmans ,
D. Nielsen ,
G.D. Snowder  and
M. Georges
N.E. Cockett
Affiliation:
Department of Animal, Dairy and Veterinary Sciences, College of Agriculture, Utah State University, Logan, UT 84322-4700
S.P. Jackson
Affiliation:
Department of Animal Science and Food Technology, Texas Tech University, Lubbock, TX 79409
T.L. Shay
Affiliation:
Department of Animal, Dairy and Veterinary Sciences, College of Agriculture, Utah State University, Logan, UT 84322-4700
F. Farnir
Affiliation:
Department of Genetics, University of Liege, Belgium
S. Berghmans
Affiliation:
Department of Genetics, University of Liege, Belgium
D. Nielsen
Affiliation:
Department of Animal, Dairy and Veterinary Sciences, College of Agriculture, Utah State University, Logan, UT 84322-4700
G.D. Snowder
Affiliation:
ARS, USDA, U.S. Sheep Experiment Station, Dubois, ID 83423
M. Georges*
Affiliation:
Department of Genetics, University of Liege, Belgium
*
1To whom correspondence should be addressed: Genetics, Faculty of Veterinary Medicine, University of Liège (B43), 20 Bd de Colonster, 4000 Liège (Sart Tilman). Email: michel@stat.fmv.ulg.ac.be
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Extract

In 1983, the occurrence of a ram exhibiting an exceptional muscular development was reported in a flock of Dorset sheep. This unusual phenotype was transmitted to some of the offspring, and subsequent matings involving hypermuscled male descendents of the founder ram and normal ewes clearly demonstrated a 50%-50%, sex-independent segregation ratio of the trait. It was therefore postulated that a dominant mutation (CLPG versus the normal clpg allele) at the autosomal “callipyge“ locus was responsible for this hypertrophy. Using the same family material, the callipyge locus was unambiguously mapped to the distal part of ovine chromosome 18 (Cockett et al., 1994).

In this paper, we present very strong evidence that the callipyge locus is subjected to a previously undescribed form of parental imprinting. It is indeed demonstrated that animals only express the callipyge phenotype if they have inherited the CLPG mutation from their sire, not if it is transmitted by the dam.

Type
Molecular Genetic Markers in Livestock Breeding
Information
Proceedings of the British Society of Animal Science , Volume 1996 , March 1996 , pp. 51
Copyright
Copyright © The British Society of Animal Science 1996

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References

Cockett, N.E.; Jackson, S.P.; Shay, T.L.; Nielsen, D.; Moore, S.S.; Steele, M.R.; Barendse, W.; Green, R.D.; Georges, M. (1994) Chromosomal localization of the callipyge gene in sheep (Ovis aries) using bovine DNA markers. Proc.Natl.Acad.Sci.USA 91:3019–3023.10.1073/pnas.91.8.3019CrossRefGoogle ScholarPubMed