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Effect of growth hormone on non insulin mediated glucose uptake in sheep

Published online by Cambridge University Press:  05 November 2021

M.T. Rose ,
Y. Obara ,
F. Itoh ,
H. Hashimoto ,
Y. Takahashi  and
K. Hodate
M.T. Rose
Affiliation:
National Institute of Animal Industry, Tsukuba Norindanchi, P.O. Box 5, Ibaraki 305 Japan
Y. Obara
Affiliation:
National Institute of Animal Industry, Tsukuba Norindanchi, P.O. Box 5, Ibaraki 305 Japan
F. Itoh
Affiliation:
National Institute of Animal Industry, Tsukuba Norindanchi, P.O. Box 5, Ibaraki 305 Japan
H. Hashimoto
Affiliation:
National Institute of Animal Industry, Tsukuba Norindanchi, P.O. Box 5, Ibaraki 305 Japan
Y. Takahashi
Affiliation:
National Institute of Animal Health, Tsukuba Norindanchi, Ibaraki 305, Japan
K. Hodate
Affiliation:
National Institute of Animal Industry, Tsukuba Norindanchi, P.O. Box 5, Ibaraki 305 Japan
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Extract

Glucose uptake by tissues is controlled by both insulin dependent and insulin independent pathways. One mechanism by which growth hormone is thought to increase the productive efficiency of ruminants is to antagonise insulin mediated glucose uptake (IMGU), thereby sparing glucose for non insulin mediated glucose uptake (NIMGU) dependent processes, such as milk production and growth (Rose and Obara, 1996). The aim of this experiment was to determine if growth hormone also has an effect on whole body NIMGU, by infusing somatostatin. Somatostatin prevents the release of insulin from the pancreas, thus, once insulin has cleared from the circulation, estimates of glucose turnover should be entirely non insulin mediated (Baron et al. 1987).

Type
Programme
Information
Proceedings of the British Society of Animal Science , Volume 1997 , 1997 , pp. 191
Copyright
Copyright © British Society of Animal Science 1997

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References

Barron, A.D., Wallace, P. & Olefsky, J.M. 1987 In vivo regulation of non-insulin-mediated and insulin-mediated glucose uptake by epinephrine. Journal of Clinical Endocrinology & Metabolism 64 889–895.CrossRefGoogle Scholar
Rose, M.T. and Obara, Y. (1996). Effect of growth hormone on the response to insulin and glucose turnover in sheep. Journal of Agricultural Science, Cambridge 126: 107–155.CrossRefGoogle Scholar
Weekes, T.E.C., Sasaki, Y. & Tsuda, T. 1983 Enhanced responsiveness to insulin in sheep exposed to cold. American Journal of Physiology 244 E335–E345.Google Scholar