Quillaja saponins are known to have immunomodulatory properties and are commonly used as vaccine adjuvants to promote immune response. Curcumin is an extract of the spice turmeric and has also been suggested to have immunomodulatory activity. Commercial weaning occurs before the piglet active immune system is developed and this alongside the withdrawal of sow milk antibodies, results in immuno-incompetence during the initial post-weaning period (Krakowski et al., 1998). The hypothesis that dietary Quillaja saponin or Curcumin will enhance piglet immune status, health and performance during the first 20 days post weaning was therefore tested.