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Effect of dietary polyunsaturated fatty acids on ex-vivo lymphocyte stimulation response to Cooperia onchophara L3 antigen in calves

  • K.N. Muturi (a1), M. Birnie (a1), M. Wallace (a1), J. Struthers (a1), J. R. Scaife (a1), M.A. Lomax (a1) and R. Barker (a2)...


Dietary polyunsaturated fatty acids (PUFA) are known to influence the fatty acid composition of immune and inflammatory cell membranes (Yaqoob et al, 1995). Changing the fatty acid composition and the n-6/n-3 PUFA ratio of cell membranes has been reported to have profound effects on immune cell functionality (Blok et al, 1996). Immune responses to Cooperia onchophara, a nematode parasite that infects calves, are usually slow to develop and inappropriate. The aim of this experiment was to establish the extent to which supplementation of pre-ruminant calves with an n-6 or n-3 PUFA source may influence ex-vivo lymphocyte response to an L3 C onchophara antigen.


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