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Effect of dietary polyunsaturated fatty acids on ex-vivo lymphocyte stimulation response to Cooperia onchophara L3 antigen in calves

  • K.N. Muturi (a1), M. Birnie (a1), M. Wallace (a1), J. Struthers (a1), J. R. Scaife (a1), M.A. Lomax (a1) and R. Barker (a2)...

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Dietary polyunsaturated fatty acids (PUFA) are known to influence the fatty acid composition of immune and inflammatory cell membranes (Yaqoob et al, 1995). Changing the fatty acid composition and the n-6/n-3 PUFA ratio of cell membranes has been reported to have profound effects on immune cell functionality (Blok et al, 1996). Immune responses to Cooperia onchophara, a nematode parasite that infects calves, are usually slow to develop and inappropriate. The aim of this experiment was to establish the extent to which supplementation of pre-ruminant calves with an n-6 or n-3 PUFA source may influence ex-vivo lymphocyte response to an L3 C onchophara antigen.

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