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The effect of dietary molybdenum or iron on copper status and trace element accumulation in the pituitary and ovary of growing lambs

Published online by Cambridge University Press:  20 November 2017

C. L. Williams ,
S. Haywood ,
M. Loughran ,
R. G. Wilkinson ,
D. V. Illingworth  and
A. M. Mackenzie
C. L. Williams*
Affiliation:
Harper Adams University College, Newport, Shropshire, TF10 8NB, UK
S. Haywood
Affiliation:
Dept. of Veterinary Pathology, University of Liverpool, Liverpool, L69 3BX, UK
M. Loughran
Affiliation:
Dept. of Veterinary Pathology, University of Liverpool, Liverpool, L69 3BX, UK
D. V. Illingworth
Affiliation:
Centre for Animal Sciences, LIBA, School of Biology, University of Leeds, LS2 9JT, UK
A. M. Mackenzie
Affiliation:
Harper Adams University College, Newport, Shropshire, TF10 8NB, UK
*
Email: cwilliams@harper-adams.ac.uk
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Extract

Secondary copper deficiency in ruminant animals is induced by high dietary levels of molybdenum (Mo), iron (Fe) or sulphur (S). Within the rumen, sulphur reacts with Mo to form a series of thiomolybdate molecules (TM) which may chelate copper. This reduces copper absorption or if TM is absorbed, inhibits copper metallo-enzyme activities. Parental administration of TM has resulted in an increase in Cu to the brain and an increase in Mo to the pituitaries (Haywood et al., 1998). This redistribution may alter neurological, endocrine and reproductive function. However, there are no reports on effects of endogenously produced TM on brain or pituitary trace element accumulation. The objective of this study was to determine the effect of dietary Mo or Fe on copper status and mineral retention in the pituitary gland and ovary of growing lambs.

Type
Sheep Nutrition
Information
Proceedings of the British Society of Animal Science , Volume 2003 , 2003 , pp. 195
Copyright
Copyright © The British Society of Animal Science 2003

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References

Haywood, S., Dincer, Z., Holding, J., Parry, N. M. 1998. Metal (molybdenum, copper) accumulation and retention in brain, pituitary and other organs of ammonium tetrathiomolybdate-treated sheep Brit. J. Nutr.s 79 (4): p 329 CrossRefGoogle ScholarPubMed