Porcine plasma is known to improve immediate post-weaning performance but this is often only evident in the first week to ten days after weaning (Toplis and Miller, 1999). Few if any studies have investigated whether there are any long term effects over the entire growth period. It has previously been shown that piglets in poor health situations (Coffey and Cromwell, 1995) demonstrate markedly greater responses to porcine plasma. The objective of this study was to determine whether porcine plasma produced long-term benefits and whether this was modulated by health challenge during the weaning period.