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Characterisation and mapping of the Booroola (FecB) gene using regression analysis in sheep

  • G.A. Walling (a1), K.G. Dodds (a1), S.M. Galloway (a2), A.E. Beattie (a1), E.A. Lord (a1), J.M. Lumsden (a2), G.W. Montgomery (a3) and J.C. McEwan (a1)...

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The Booroola Merino strain of sheep carries a major autosomal mutation (FecB) which increases ovulation rate (Davis et al., 1982). To map the gene, heterozygous sires (B+) were mated to non-carrier ewes (++). The female progeny were then examined by laproscopy to determine ovulation rates and these phenotypes used to assign progeny genotypes (B+, ++ or undetermined). Linkage analysis between the assigned Booroola genotype and a set of marker genotypes was used to assign the Booroola gene to a region of sheep chromosome 6 (OOV6) (Montgomery et al., 1994). These studies relied on accurate genotype assignment and a constant gene effect across animals and breeding seasons. This study aims to use regression analysis to verify the validity of these assumptions.

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Davis, G.H., Montgomery, G.W., Allison, J.A., Kelly, R.W. and Bray, A.R. 1982. Segregation of a major gene influencing fecundity in progeny of Booroola sheep. New Zealand Journal of Agricultural Research 25: 525529
Dodds, K.G. 1999. Haley-Knott regression mapping of quantitative trait loci in extended pedigrees. Proceedings of the Association for the Advancement of Animal Breeding and Genetics 13: 313316.
Montgomery, G.W. and Hawker, H. 1987. Seasonal reproduction in ewes selected on seasonal changes in wool production. Journal of Reproductive Fertility 79: 207213.
Montgomery, G.W., Lord, E.A., Penty, J.M., Dodd, K.G., Broad, T.E., Cambridge, L., Sunden, S.L.F., Stone, R.T. and Crawford, A.M. 1994. The Booroola fecundity (FecB) gene maps to sheep chromosome 6. Genomics 22: 148153.

Characterisation and mapping of the Booroola (FecB) gene using regression analysis in sheep

  • G.A. Walling (a1), K.G. Dodds (a1), S.M. Galloway (a2), A.E. Beattie (a1), E.A. Lord (a1), J.M. Lumsden (a2), G.W. Montgomery (a3) and J.C. McEwan (a1)...

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