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Nutritional and hormonal regulation of hepatic IGF-1 production in sheep and rats

Published online by Cambridge University Press:  24 November 2017

Q.J. Luo  and
J.C. MacRae
Q.J. Luo
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
J.C. MacRae
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Extract

Circulating concentrations of insulin-like growth factor-1 (IGF-1) are closely related to the nutrition of animals and their rates of growth. The major site of IGF-1 production is thought to be the liver. Whilst growth hormone (GH) is thought to be the main regulator of IGF-1 production in farm animals, in laboratory rats, altering the GH status of the animal (without hyperphysectomy) has little influence on circulating IGF-1 levels. A series of studies have been conducted with primary cultured rat and sheep hepatocytes to investigate the influence of GH and nutrient availability on the production of IGF-1 by liver cells.

Type
Ruminant Metabolism
Information
Proceedings of the British Society of Animal Production (1972) , Volume 1993: Winter meeting , March 1993 , pp. 192
Copyright
Copyright © The British Society of Animal Production 1993

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References

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