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The Effect of Repeated Hypoglycaemia on Plasma β-Endorphin in Gilts

Published online by Cambridge University Press:  21 November 2017

F. L. Chiang
Affiliation:
Department of Animal Physiology and Nutrition, University of Leeds, Leeds LS2 9JT
R. G. Rodway
Affiliation:
Department of Animal Physiology and Nutrition, University of Leeds, Leeds LS2 9JT
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Extract

The activation of the hypothalamic-pituitary-adrenal axis is one of the best studied stress-related responses. In particular, the involvement of endogenous opioid peptides in response to pltysiological and pharmacological stimuli has been the subject of extensive study both in man and other animals (Nakao, 1979, Petraglia, 1985, Engler, 1988). However, in animal models of repeated stress, the acute response to a stressor often habituates when the stressor is presented repeatedly (Ottenweller, 1991). Hypoglycaemia is a stress which can be easily and repeatedly applied to experimental animals. The present study was performed to determine whether insulin-induced hypogrycaemia enhances the release of β-endorphin in pigs, and whether this response is maintained over repeated treatments on consecutive days.

Type
Pigs
Copyright
Copyright © The British Society of Animal Production 1994

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References

Engler, D., Pham, T., Fullerton, M.J., Funder, J.W. and Clark, L.J. (1988). Studies of the egulation of the hypothalantic-pituitary-adrenal axis in sheep with hypothalamic-pituitary disconnection I. Effect of an audiovisual stimulus and insulin-induced hypoglycaemia. Neuroendocrinology 48: 551560.CrossRefGoogle Scholar
Nakao, K., Nakai, Y., Jinganti, H., Oki, S., Fukata, J, and Imura, H. (1979). Substantial rise of plasma β-endorphin levels after insulin-induced hypoglycaemia in human subjects. J Clin Endocrinol Metab 49: 838841.CrossRefGoogle ScholarPubMed
Ottenweller, J.E., Servathts, R.J., Tapp, W.N., Drastal, S.D., Bergen, M.T. and Nateison, B.H. (1992). A chronic stress state in rats: Effects of repeated stress on basal corticosterone and behaviour. Physiol. Behav. 51: 689698.CrossRefGoogle Scholar
Petraglia, F., Facchinetti, F., D'ambrogio, G., Voipe, A. and Genazzani, A. R. (1986). Somatostatin and oxytocin infusion inhibits the rise of plasma β-endorphin, β-lipotrophin and Cortisol induced by insulin hypoglycaemia. Clinical Endocrinology 24: 609616.CrossRefGoogle ScholarPubMed

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