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Systematic Studies of Cerebral Resuscitation Potentials after Global Brain Ischemia (GBI)

Published online by Cambridge University Press:  28 June 2012

Sven Erik Gisvold  and
Peter Safar
Sven Erik Gisvold
Affiliation:
From the Resuscitation Research Center and the Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh, Pittsburgh PA 15260, USA.
Peter Safar
Affiliation:
From the Resuscitation Research Center and the Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh, Pittsburgh PA 15260, USA.
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Extract

Resuscitation of the brain after ischemic-anoxic brain injury remains a controversial topic. There is, however, presently a certain therapeutic optimism in this field. Ours is partly based on the recognition of a post-resuscitation disease, that is, treatable pathologic processes in all organs after restoration of adequate perfusion pressure and arterial oxygenation. Also, Hossmann has shown that neurons can survive longer periods of anoxia than previously assumed.

There have been reports on experimental focal ischemia indicating beneficial effects of barbiturates and moderate hemodilution before and after initiation of focal ischemia. After complete temporary global brain ischemia (GBI), as in cardiac arrest, however, results so far have been conflicting and controversial.

Type
Part II: Clinical Care Topics
Information
Prehospital and Disaster Medicine , Volume 1 , supplement S1: Disaster Resuscitology , 1985 , pp. 255 - 260
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1985

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