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Irreversible Hemorrhagic Shock Model in the Monkey

Published online by Cambridge University Press:  28 June 2012

Gad Bar-Joseph ,
Peter Safar  and
William S. Stezoski
Gad Bar-Joseph
Affiliation:
From the Resuscitation Research Center and the Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh. Pittsburgh PA 15260, USA.
Peter Safar
Affiliation:
From the Resuscitation Research Center and the Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh. Pittsburgh PA 15260, USA.
William S. Stezoski
Affiliation:
From the Resuscitation Research Center and the Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh. Pittsburgh PA 15260, USA.
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Extract

In spite of extensive research, the question of fluid therapy for hemorrhagic shock is still controversial. Certain drawbacks in the experimental models are among the reasons for this controversy. These drawbacks are mainly related to the animal species used, to the way the shock insult is initiated and to the effects of deep anesthesia on the response to shock.

Dogs were used in more than 90% of shock studies—although their response to bleeding is different from the human response. The dog has a large, contractile spleen, which can modify its cardiovascular response to bleeding.

Type
Part II: Clinical Care Topics
Information
Prehospital and Disaster Medicine , Volume 1 , supplement S1: Disaster Resuscitology , 1985 , pp. 169 - 170
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1985

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References

1. Wiggers, HC, Ingraham, RC. Hemorrhagic, shock: Definition and criteria for its diagnosis. J Clin Invest 1946;25:30.CrossRefGoogle ScholarPubMed
2. Swan, H. Experimental acute hemorrhage. Arch Surg 1965;91:390.CrossRefGoogle ScholarPubMed
3. Rutherford, RB, Arora, S, Fleming, PWet al. Delayed-onset pulmonary insufficiency in primates resuscitated from hemorrhagic shock. J Trauma 1979 19:422CrossRefGoogle ScholarPubMed