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Crystal structure of choline fenofibrate (Trilipix®), (C5H14NO) (C17H14ClO4)

  • James A. Kaduk (a1), Kai Zhong (a2), Amy M. Gindhart (a2) and Thomas N. Blanton (a2)

Abstract

The crystal structure of choline fenofibrate has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional techniques. Choline fenofibrate crystallizes in space group Pbca (#61) with a = 12.341 03(2), b = 28.568 70(6), c = 12.025 62(2) Å, V = 4239.84(1) Å3, and Z = 8. The hydroxyl group of the choline anion makes a strong hydrogen bond to the ionized carboxylate group of the fenofibrate anion. Together with C–H···O hydrogen bonds, these link the cations and anions into layers parallel to the ac-plane. The powder pattern has been submitted to ICDD for inclusion in the Powder Diffraction File™.

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a) Author to whom correspondence should be addressed. Electronic mail: kaduk@polycrystallography.com

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Crystal structure of choline fenofibrate (Trilipix®), (C5H14NO) (C17H14ClO4)

  • James A. Kaduk (a1), Kai Zhong (a2), Amy M. Gindhart (a2) and Thomas N. Blanton (a2)

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