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Transplanting Nuclei between Human Eggs: Implications for Germ-Line Genetics

Published online by Cambridge University Press:  17 May 2016

Andrea L. Bonnicksen*
Affiliation:
Northern Illinois University, USA
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Abstract

It has been suggested that diseases linked to mutations in mitochondrial DNA (mtDNA) might be circumvented by transferring the nucleus from the egg of a woman with a mitochondrial disease to a donor egg from which the nucleus has been removed and discarded. Egg cell nuclear transfer would be a straightforward technique for preventing serious diseases, relying on a procedure used in embryo or somatic cell cloning. It might present a relatively uncontentious setting for the refinement of cloning procedures. Its proposal creates the opportunity to identify categories of germ-line interventions; explore whether ethical issues vary according to the category of germ-line intervention; and craft more precise policy guidelines in which graduated levels of germ-line interventions are recognized.

Type
Roundtable Article
Copyright
Copyright © Association for Politics and the Life Sciences 

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References

Anderson, W.F. (1987). “Human Gene Therapy: Scientific and Ethical Considerations.” In Chadwick, R.F. (ed.), Ethics, Reproduction and Genetic Control. London: Croon Helm.Google Scholar
“Austria. Federal Law of 1992 (Serial No. 275) regulating medically assisted procreation (the Reproductive Medicine Law), and amending the General Civil Code, the Marriage Law, and the Rules of Jurisdiction. Date of entry into force: 1 July 1992. (Bundesgesetzblatt fur die Republik Osterreich, 4 June 1992, No. 105, pp. 1299-1304). Austr. 93.1” (1993). International Digest of Health Legislation 44(2):247–48.Google Scholar
Bacchetta, M.D. and Richter, G. (1996). “Response to ‘Germ-Line Therapy to Cure Mitochondrial Disease: Protocol and Ethics of In Vitro Ovum Nuclear Transplantation’ by Donald S. Rubenstein, David C. Thomasma, Eric A. Schon, and Michael J. Zinaman (CQ Vol 4, No 3).” Cambridge Quarterly of Healthcare Ethics 5(3):450–57.CrossRefGoogle Scholar
Campbell, K.H.S., McWhir, J., Ritchie, W.A., and Wilmut, I. (1996). “Sheep Cloned by Nuclear Transfer from a Cultured Cell Line.” Nature 380 (March 7):6466.Google Scholar
Cherfas, J. (1982). Man-Made Life. New York: Pantheon Books.Google Scholar
Cook-Deegan, R.M. (1990). “Human Gene Therapy and Congress.” Human Gene Therapy 1:163–70.Google Scholar
“Document from the Parliamentary Assembly of the Council of Europe, 1982, Thirty-Third Ordinary Session Recommendation 934 (1982) on Genetic Engineering” (1991). Human Gene Therapy 2:327–28.Google Scholar
Federal Register (1990). 55:7438–48 (March 1).Google Scholar
Fletcher, J.C. and Anderson, W.F. (1992). “Germ-Line Gene Therapy: A New Stage of Debate.” Law, Medicine and Health Care 20(1-2):2639.Google Scholar
Gardner, W. (1995). “Can Human Genetic Enhancement Be Prohibited?” Journal of Medicine and Philosophy 20(1):6584.Google Scholar
“German Embryo Protection Act (October 24th, 1990): Gesetz zum Schutz von Embryonen” (1991). Human Reproduction 6(4):605606.Google Scholar
Hall, J.L., Engel, D., Gindoff, P.R., Mottla, G.L., and Stillman, R.J. (1993). “Experimental Cloning of Human Polyploid Embryos Using an Artificial Zona Pellucida.” Paper presented at the annual meeting of the American Fertility Society (Program Supplement), Montreal.Google Scholar
Hotchkiss, R.D. (1965). “Portents for a Genetic Engineering.” Journal of Heredity 56(5):197202.Google Scholar
Hubbard, R. and Wald, E. (1993). Exploding the Gene Myth. Boston: Beacon Press.Google Scholar
“Human Fertilisation and Embryology Act 1990” (1991). International Digest of Health Legislation 42(1):6985.Google Scholar
Kolata, G. (1997a). “Lab Yields Lamb with Human Gene.” New York Times (July 25).Google Scholar
Kolata, G. (1997b). “Scientists Face New Ethical Quandaries in Baby-Making.” New York Times (August 19).Google Scholar
Meng, L. and Wolf, D.P. (1996). “Nuclear Transfer in the Rhesus Monkey.” Abstracts of the 51st Annual Meeting of the American Society for Reproductive Medicine. Seattle, October: S236.Google Scholar
Munson, R. and Davis, L.H. (1992). “Germ-Line Gene Therapy and the Medical Imperative.” Kennedy Institute of Ethics Journal 2(2):137–38.CrossRefGoogle Scholar
National Institutes of Health, Report of the Human Embryo Research Panel. Final Draft. September 27, 1994.Google Scholar
Pergament, E. and Bonnicksen, A. (1994). “Preimplantation Genetics: A Case for Prospective Action.” American Journal of Medical Genetics 52:151–57.CrossRefGoogle Scholar
Pennisi, E. and Williams, N. (1997). “Will Dolly Send in the Clones?” Science 275:1415–16.Google Scholar
Peters, T. (1995). “‘Playing God’ and Germline Intervention.” Journal of Medicine and Philosophy 20(4):365–78.CrossRefGoogle Scholar
“Position Paper on Human Germ Line Manipulation Presented by Council for Responsible Genetics, Human Genetics Committee, Fall, 1992” (1993). Human Gene Therapy 4(1):3537.Google Scholar
Resnick, D. (1994). “Debunking the Slippery Slope against Human Germ-Line Gene Therapy.” Journal of Medicine and Philosophy 19(1):230–40.Google Scholar
Royal Commission on New Reproductive Technologies (1993). Proceed with Care: Final Report of the Royal Commission on New Reproductive Technologies. Ottawa: Minister of Government Services Canada.Google Scholar
Rubenstein, D.S., Thomasma, D.C., Schon, E.A., and Zinaman, M.J. (1995). “Germ-Line Therapy to Cure Mitochondrial Disease: Protocol and Ethics of In Vitro Ovum Nuclear Transplantation.” Cambridge Quarterly of Healthcare Ethics 4(3):316–39.CrossRefGoogle Scholar
S.B. 1344. (1997). “Human Cloning.” California. Signed into law October 4.Google Scholar
Solter, D. (1996). “Lambing by Nuclear Transfer.” Nature 380 (March 7):2425.Google Scholar
Stephenson, J. (1996). “A Role for Mitochondria in Age-Related Disorders?” Journal of the American Medical Association 275(20):1531–32.Google Scholar
Suzuki, D. and Knudtson, P. (1990). Genethics: The Clash Between the New Genetics and Human Values. Cambridge, MA: Harvard University Press.Google Scholar
“Sweden. Law No. 115 of 14 March 1991 concerning measures for the purposes of research or treatment in connection with fertilized human oocytes. (Svensk forfattningssamling, 1991, 26 March 1991, 2 pp.) Swed. 93.2” (1993). International Digest of Health Legislation 44(1):58.Google Scholar
Walters, L. (1991). “Human Gene Therapy: Ethics and Public Policy.” Human Gene Therapy 2(2):115–22.Google Scholar
Wilmut, I., Schnieke, A.E., McWhir, J., Kind, A.J., Campbell, K.H.S. (1997). “Viable Offspring Derived from Fetal and Adult Mammalian Cells.” Nature 385:810–13.Google Scholar
Zhang, J., Grifo, J., Blaszczk, A., Meng, L., Adler, A., Chin, A., Krey, L., NYU Medical Center Program for IVF, New York, NY, and Oregon Regional Primate Research Center, Beaverton, OR (1997). “In Vitro Maturation (IVM) of Human Preovulatory Oocytes Reconstructed by Germinal Vesicle (GV) Transfer.” Paper presented at the annual meeting of the American Society for Reproductive Medicine, Cincinnati (Program Supplement).Google Scholar
Zimmerman, B.K. (1991). “Human Germ-Line Therapy: The Case For Its Development and Use.” Journal of Medicine and Philosophy 6(6):593612.Google Scholar