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Biopsychosocial distress and clinical outcome in metastatic renal cell carcinoma

  • Cristiane Decat Bergerot (a1), Karen Lynn Clark (a1), Kimlin Tam Ashing (a2), Paulo Gustavo Bergerot (a1), Richard Obenchain (a3), Nazli Dizman (a1), JoAnn Hsu (a1), Errol Philip (a4), Matthew Loscalzo (a3) and Sumanta Kumar Pal (a1)...



Limited research exists examining the biopsychosocial experience of patients diagnosed with metastatic renal cell carcinoma (mRCC), a disease commonly associated with a poor prognosis. The purpose of this study was to describe rates and types of distress in mRCC patients and explore the relationship between distress and overall survival.


A cohort of 102 patients with mRCC treated at a single institution was assessed by a touch screen–based instrument comprising 22 core items spanning physical, practical, functional, and emotional domains. Association between biopsychosocial distress and clinicopathologic criteria was interrogated. Overall survival was compared between patients with low distress versus high distress.


High rates of distress (20.7%) were found among patients newly diagnosed with mRCC. Among those domains contributing to distress, pain, fatigue, and financial comorbidity were the most commonly reported by patients with mRCC. A trend toward poorer overall survival in those patients with high distress versus low distress was observed among mRCC patients.

Significance of results

Based on data from a relatively large sample of patients, this study provides the first specific insights into the potential impact of biopsychosocial distress and outcomes among patients with mRCC.


Corresponding author

Author for correspondence: Sumanta K. Pal, M.D., Department of Medical Oncology & Experimental Therapeutics, 1500 East Duarte Road, Duarte, CA 91010. E-mail:


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