Skip to main content Accessibility help
×
Home

A case of respiratory akathisia in a cancer patient: A case report

Published online by Cambridge University Press:  19 February 2008

Yu Sunakawa
Affiliation:
Department of Clinical-Oncology, Comprehensive Cancer Center, Saitama Medical University International Medical Center, Saitama, Japan
Makoto Wada
Affiliation:
Department of Psycho-Oncology, Comprehensive Cancer Center, Saitama Medical University International Medical Center, Saitama, Japan
Tomomi Nishida
Affiliation:
Department of Psycho-Oncology, Comprehensive Cancer Center, Saitama Medical University International Medical Center, Saitama, Japan
MEI Wada
Affiliation:
Department of Psycho-Oncology, Comprehensive Cancer Center, Saitama Medical University International Medical Center, Saitama, Japan
Kazuhiro Araki
Affiliation:
Department of Clinical-Oncology, Comprehensive Cancer Center, Saitama Medical University International Medical Center, Saitama, Japan
Hisashi Endo
Affiliation:
Department of Clinical-Oncology, Comprehensive Cancer Center, Saitama Medical University International Medical Center, Saitama, Japan
Fumio Nagashima
Affiliation:
Department of Clinical-Oncology, Comprehensive Cancer Center, Saitama Medical University International Medical Center, Saitama, Japan
Wataru Ichikawa
Affiliation:
Department of Clinical-Oncology, Comprehensive Cancer Center, Saitama Medical University International Medical Center, Saitama, Japan
Toshimichi Miya
Affiliation:
Department of Clinical-Oncology, Comprehensive Cancer Center, Saitama Medical University International Medical Center, Saitama, Japan
Hideki Onishi
Affiliation:
Department of Psycho-Oncology, Comprehensive Cancer Center, Saitama Medical University International Medical Center, Saitama, Japan
Masaru Narabayashi
Affiliation:
Department of Clinical-Oncology, Comprehensive Cancer Center, Saitama Medical University International Medical Center, Saitama, Japan Department of Palliative Medicine, Comprehensive Cancer Center, Saitama Medical University International Medical Center, Saitama, Japan
Yasutsuna Sasaki
Affiliation:
Department of Clinical-Oncology, Comprehensive Cancer Center, Saitama Medical University International Medical Center, Saitama, Japan
Corresponding
E-mail address:

Abstract

Objective:

It has been reported that akathisia is a neurological side effect induced by antiemetic drugs and/or antipsychotics. Akathisia can occur in any area of the body, but respiratory akathisia is an unusual type of akathisia. Cases of respiratory akathisia in cancer patients taking antiemetic drugs have not previously been reported.

Methods:

We report on a case of a cancer patient taking prochlorperazine as an antiemetic drug who experienced dyspnea accompanied by severe restlessness associated with respiration. By administration of biperiden, his restlessness in respiration and dyspnea promptly disappeared.

Results:

This finding led us to conclude that this cancer patient was experiencing respiratory akathisia.

Significance of results:

Respiratory akathisia is uncommon. It is important for cancer patients that dyspnea induced by disease progression be ruled out as a cause of the respiratory restlessness. It is necessary to consider the possibility of akathisia in patients that complain of vague anxiety, chest discomfort, or dyspnea following antipsychotic medication.

Type
Case Report
Copyright
Copyright © Cambridge University Press 2008

Access options

Get access to the full version of this content by using one of the access options below.

References

Bateman, D.N., Darling, W.M., Boys, R., et al. (1989). Extrapyramidal reactions to metoclopramide and prochlorperazine. Quarterly Journal of Medicine, 71, 307311.Google ScholarPubMed
Blaisdell, G.D. (1994). Akathisia: A comprehensive review and treatment summary. Pharmacopsychiatry, 27, 139146.CrossRefGoogle Scholar
Burris, H., Hesketh, P., Cohn, J., et al. (1996). Efficacy and safety of oral granisetron versus oral prochlorperazine in preventing nausea and emesis in patients receiving moderately emetogenic chemotherapy. The Cancer Journal from Scientific American, 2, 8590.Google ScholarPubMed
Crucitt, M.A., Hyman, W., Grote, T., et al. (1996). Efficacy and tolerability of oral ondansetron versus prochlorperazine in the prevention of emesis associated with cyclophosphamide-based chemotherapy and maintenance of health-related quality of life. Clinical Therapeutics, 18, 778788.CrossRefGoogle ScholarPubMed
Dressler, D. & Benecke, R. (2005). Diagnosis and management of acute movement disorders. Journal of Neurology, 252, 12991306.CrossRefGoogle ScholarPubMed
Esmail, Z., Montgomery, C., Courtrn, C., et al. (1999). Efficacy and complications of morphine infusions in postoperative paediatric patients. Paediatric Anaesthesia, 9, 321327.CrossRefGoogle ScholarPubMed
Fleishman, S.B., Lavin, M.R., Sattler, M., et al. (1994). Antiemetic-induced akathisia in cancer patients receiving chemotherapy. American Journal of Psychiatry, 151, 763765.Google ScholarPubMed
Gibb, W.R.G. & Lee, A. (1986). The clinical phenomenon of akathisia. Journal of Neurology, Neurosurgery, and Psychiatry, 49, 861866.CrossRefGoogle ScholarPubMed
Heard, K., Daly, F.F., O'Malley, G., et al. (1999). Respiratory distress after use of droperidol for agitation. Annals of Emergency Medicine, 34, 410411.CrossRefGoogle ScholarPubMed
Hirose, S. (2000). Restlessness of respiration as a manifestation of akathisia: Five case reports of respiratory akathisia. Journal of Clinical Psychiatry, 61, 737741.CrossRefGoogle ScholarPubMed
Hirose, S. & Ashby, C.R. (2000). Intravenous biperiden in akathisia: An open pilot study. International Journal of Psychiatry in Medicine, 30, 185194.CrossRefGoogle Scholar
Kruk, J., Sachdev, P., Singh, S. (1995). Neuroleptic-induced respiratory dyskinesia. The Journal of Neuropsychiatry and Clinical Neurosciences, 7, 223229.Google ScholarPubMed
Matsui-Sakata, A., Ohtani, H., & Sawada, Y. (2005). Pharmacokinetic-pharmacodynamic analysis of antipsychotics-induced extrapyramidal symptoms based on receptor occupancy theory incorporating endogenous dopamine release. Drug Metabolism and Pharmacokinetics, 20, 187199.CrossRefGoogle ScholarPubMed
Raskin, D.E. (1972). Akathisia: A side effect to be remembered. American Journal of Psychiatry, 129, 345347.CrossRefGoogle ScholarPubMed
Ratey, J.J. & Salzman, C. (1984). Recognizing and managing akathisia. Hospital and Community Psychiatry, 35, 975977.Google ScholarPubMed
Seeman, P. (2002). Atypical antipsychotics: Mechanism of action. Canadian Journal of Psychiatry, 47, 2738.CrossRefGoogle ScholarPubMed
Tsuji, Y., Miyama, S., Uemura, Y., et al. (2006). Three cases of drug-induced akathisia due to antiemetics during cancer palliative care. Gan To Kagaku Ryoho, 33, 267269.Google ScholarPubMed
Walters, A.S., Hening, W., Chokroverty, S., et al. (1989). Restlessness of the arms as the principal manifestation of neuroleptic-induced akathisia [letter]. Journal of Neurology, 236, 435.CrossRefGoogle Scholar

Full text views

Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.

Total number of HTML views: 2
Total number of PDF views: 18 *
View data table for this chart

* Views captured on Cambridge Core between September 2016 - 17th January 2021. This data will be updated every 24 hours.

Hostname: page-component-77fc7d77f9-w9qs9 Total loading time: 0.298 Render date: 2021-01-17T22:10:02.269Z Query parameters: { "hasAccess": "0", "openAccess": "0", "isLogged": "0", "lang": "en" } Feature Flags last update: Sun Jan 17 2021 22:02:30 GMT+0000 (Coordinated Universal Time) Feature Flags: { "metrics": true, "metricsAbstractViews": false, "peerReview": true, "crossMark": true, "comments": true, "relatedCommentaries": true, "subject": true, "clr": true, "languageSwitch": true, "figures": false, "newCiteModal": false, "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true }

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

A case of respiratory akathisia in a cancer patient: A case report
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

A case of respiratory akathisia in a cancer patient: A case report
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

A case of respiratory akathisia in a cancer patient: A case report
Available formats
×
×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *