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Towards Radiolabeled G∧C Module for Cellular Imaging of Bioactive Rosette Nanotubes

Published online by Cambridge University Press:  02 March 2011

Alaaeddin Alsbaiee ,
Mustapha St. Jules ,
Rachel L. Beingessner  and
Hicham Fenniri
Hicham Fenniri
Affiliation:
National Institute for Nanotechnology, Edmonton, T6G2M9, Canada Department of Chemistry, University of Alberta, Edmonton, T6G2M9, Canada
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Abstract

Rosette nanotubes (RNTs) are obtained through the self-organization of biologically inspired self-complementary guanine-cytosine modules (G∧C motif) under physiological conditions. These architectures can express bioactive molecules on their surface by functionalizing the G∧C motif prior to self-assembly. As a result, RNTs are promising drug delivery vehicles for the treatment of diseases such as cancer and inflammatory disorders. Towards these studies, we have explored the toxicity and immunological response of RNTs and are now focused on understanding their cellular uptake, biological distribution and kinetics in vivo. For these investigations, we need to construct a RNT labeled with a radionuclide that can be followed in vivo by SPECT (single photon emission computed tomography) imaging. In this proceeding, we describe a twin G∧C motif that is functionalized with mercaptoacetyl triglycine (MAG3). This is a well known ligand which is able to form a stable chelate with the radionuclides 99mTc or 186/188Re. In order to develop the chemistry for this radiolabeling strategy for the RNTs, we demonstrate the chelation of the MAG3 functionalized twin-G∧C motif with cold rhenium and investigate the self-assembly properties of the complex into RNTs under aqueous conditions.

Keywords

self-assemblybiomedicalnanostructure
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1316: Symposium QQ – Nanofunctional Materials, Nanostructures and Nanodevices for Biomedical Applications II , 2011 , mrsf10-1316-qq03-12
Copyright
Copyright © Materials Research Society 2011

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