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Synthesis and Characterization of Water Soluble Block Copolymers for pH-Sensitive Delivery

  • Brian C. Anderson (a1) (a2), Paul D. Bloom (a3) (a2), Valerie V. Sheares (a3) (a2) and Surya K. Mallapragada (a1) (a2)

Abstract

A novel, water-soluble AB-block copolymer of diethylaminoethyl methacrylate (DEAEM) and poly(ethylene glycol) (PEG) was synthesized by anionic polymerization. Poly(ethylene glycol) methyl ether (PEGME) was converted into the corresponding potassium salt by reacting with potassium metal. The PEG salt was used as a macroinitiator for the polymerization of DEAEM to yield a PEG-b-PDEAEM block copolymer. Carbon dioxide was used to terminate DEAEM polymerization with a carboxylic acid group. This polymer, loaded with dye, was tested for pH sensitivity by release studies into solutions of various pH.

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