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Surface controlled nanospheres as drug carriers for intravenous and intranasal administration

Published online by Cambridge University Press:  10 February 2011

R. Gref ,
P. Quellec ,
E. Dellacherie ,
M. Tobio  and
M. J. Alonso
R. Gref
Affiliation:
Laboratoire de Chimie Physique Macromoléculaire, ENSIC, Nancy, France
P. Quellec
Affiliation:
Laboratoire de Chimie Physique Macromoléculaire, ENSIC, Nancy, France
E. Dellacherie
Affiliation:
Laboratoire de Chimie Physique Macromoléculaire, ENSIC, Nancy, France
M. Tobio
Affiliation:
Universidad de Santiago, Laboratorio de Farmacia Galénica, Santiago de Compostella, Spain
M. J. Alonso
Affiliation:
Universidad de Santiago, Laboratorio de Farmacia Galénica, Santiago de Compostella, Spain
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Abstract

The arival on the market of new therapeutic and antigenic molecules requires the development of appropriate delivery systems. The design of injectable nanoparticulate drug caniers invisible to the mononuclear phagocyte system is a major challenge. Also, overcoming mucosa baniers, such as the nasal one, using biodegradable nanospheres is another strategy still to be explored. These routes of administration require nanoparticulate systems with optimized surface properties. We investigated the ability of polyethylene glycol (PEG)-coated nanospheres made of amphiphilic diblock copolymers to achieve these goals. After an optimization of the nanosphere surface properties, we studied the possibility of entrapping macromolecules within the PEG-coated nanospheres. Results showed that it is possible to encapsulate a model protein, human serum albumin (HSA) within monodisperse nanospheres of a mean diameter of about 200 nm, reaching loadings as high as 9% (w/w). Moreover, these nanospheres showed excellent abilities for the transport of a model antigen, tetanus toxoid (Tr) through the nasal mucosa.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 501: Symposium FF – Surface Controlled Nanoscale Materials for High-Added… , 1997 , 273
Copyright
Copyright © Materials Research Society 1998

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