Skip to main content Accessibility help

Studies on the Interaction of Water-Soluble Fullerols with BSA and the Effects of Metallic Ions

  • Xu Bingshe (a1), Liu Xuguang (a1), Yan Xiaoqin (a1), Qiao Jinli (a2) and Jin Weijun (a3)...


The interaction of water-soluble C60 derived fullerols with bovine serum albumin (BSA) in physiological environment was studied in detail by the fluorescence method. Experiments showed that the interaction of fullerols with BAS is mainly in the manner of non-covalent hydrogen bond. Based on the measurements of fluorescence intensity, the apparent binding constant K and the binding site number n were obtained with K=4000 and n=1, and the energy transfer efficiency in the reaction is 0.63. Besides, the effects of metallic ions such as Cu2+, Fe3+ and Cr(VI) on the interaction of fullerols with BSA were investigated. It was found that the effects of the metallic ions are quite different from each other. Low concentrations of Cu2+ can promote the interactions between fullerols and BSA, while high concentrations of Fe3+ or Cr(VI) favorite the interactions between fullerols and BSA.



Hide All
1. Wang, Y., Cheng, L.T., J. Phys. Chem., 96(4), 1530 (1992)
2. Sijbesma, R., Srdannov, G., Wudl, F., Castoro, J.A., Wilkins, C., Friedman, S.H., De Camp, D.L. and Kenyon, G.L., J. Am. Chem. Soc., 115(15), 6510 (1993)
3. Chiang, L.Y., Lu, F.G., Lin, J.T., J. Chem. Soc., Chem. Commun., 12, 1283 (1995)
4. She, Y. M., Ji, Y. P., He, Y. F. and Liu, S. Y., Chem. J. Chinese Univ., 19(11), 1735 (1998)
5. Yan, X.Q., Liu, X.G., Qiao, J.L., Jin, W.J. and Xu, B.S., International Journal of Materials and Product Technology, (2001) accepted
6. Li, T.B., Huang, K.X., Li, X.H., Jiang, H.Y., Li, J., Yan, X. Z., Cai, J. and Zhao, S.K., Chem. J. Chinese Univ., 19(6), 858 (1998)
7. Chen, G.Z., Huang, X.Z., and Xu, J.G., in The Development of Fluorescence Analysis, (Xiamen University Press, Fujian, China, 1991), p 174
8. Feng, X.Z., Jin, R.X., Qu, Y. and He, H.W., Chem. J. Chinese Univ., 17(6), 866 (1996)


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed