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Silicon Carbide Waveguides for Optogenetic Neural Stimulation

Published online by Cambridge University Press:  25 May 2012

Joseph Register ,
Andreas Muller ,
Justin King ,
Edwin Weeber ,
Christopher L. Frewin  and
Stephen E. Saddow
Joseph Register
Affiliation:
Department of Electrical Engineering, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620
Andreas Muller
Affiliation:
Department of Physics, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620
Justin King
Affiliation:
Department of Electrical Engineering, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620
Edwin Weeber
Affiliation:
Department of Molecular Pharmacology and Physiology, USF, 4202 East Fowler Avenue, Tampa, Florida 33620
Christopher L. Frewin
Affiliation:
Department of Molecular Pharmacology and Physiology, USF, 4202 East Fowler Avenue, Tampa, Florida 33620
Stephen E. Saddow
Affiliation:
Department of Electrical Engineering, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620 Department of Molecular Pharmacology and Physiology, USF, 4202 East Fowler Avenue, Tampa, Florida 33620
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Abstract

In this paper we present a microfabricated SiC based alternative to glass-fiber optogenetic stimulation. The glass fiber system currently used for stimulation has numerous drawbacks. First, the very presence of glass can evoke an immune response in cortical tissue that can impede the light-to-neuron optical interface. This glial scarring of brain tissue effectively lowers the spatial resolution and power output of the system. Second, the fragility of an implanted glass fiber is a problem that has yet to be fully addressed. Using SiC the proposed optical structure will address these problems by significantly lowering the amount glial scarring and astrocytic activity expressed as a result of the implant. In addition, single crystal SiC allows for a flexible device that can move with the surrounding tissue without fracturing. Finally, the current glass fibers tend be single channel devices with a single ended emitter. The proposed microfabricated device will allow for multiple channels, multiple wavelengths of stimulation, and electrical feedback on each channel improving upon the current standard.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1433: Symposium H – Silicon Carbide 2012--Materials, Processing and Devices , 2012 , mrss12-1433-h04-20
Copyright
Copyright © Materials Research Society 2012

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References

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