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Selective Killing of Ovarian Cancer Cells through Induction of Apoptosis by a Nonequilibrium Atmospheric Pressure Plasma

  • Hiromasa Tanaka (a1), Sachiko Iseki (a1), Kae Nakamura (a2), Moemi Hayashi (a2), Hiroki Kondo (a1), Hiroaki Kajiyama (a2), Hiroyuki Kano (a3), Fumitaka Kikkawa (a2) and Masaru Hori (a1)...

Abstract

Two independent ovarian cancer cell lines and fibroblast controls were treated with nonequilibrium atmospheric pressure plasma (NEAPP). Most ovarian cancer cells were detached from the culture dish by continuous plasma treatment to a single spot on the dish. Next, the plasma source was applied over the whole dish using a robot arm. In vitro cell proliferation assays showed that plasma treatments significantly decreased proliferation rates of ovarian cancer cells compared to fibroblast cells. FACS and Western blot analysis showed that plasma treatment of ovarian cancer cells induced apoptosis. NEAPP could be a promising tool for therapy for ovarian cancers.

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Keywords

Selective Killing of Ovarian Cancer Cells through Induction of Apoptosis by a Nonequilibrium Atmospheric Pressure Plasma

  • Hiromasa Tanaka (a1), Sachiko Iseki (a1), Kae Nakamura (a2), Moemi Hayashi (a2), Hiroki Kondo (a1), Hiroaki Kajiyama (a2), Hiroyuki Kano (a3), Fumitaka Kikkawa (a2) and Masaru Hori (a1)...

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