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Segmented Polyurethane/Collagen Blends for Biomedical Application

  • Erkesh O Batyrbekov (a1), Rinat Iskakov (a2), Gulsharat Esenalina (a3), Aman Kurashev (a4), Maria Kim (a5) and Bulat Zhubanov (a6)...

Abstract

In the present study the preparation of biomedical devices and some biomedical application of implantable devices based on segmented polyurethane (SPU)/collagen blends have been described. SPU with different content of hard and soft segments were synthesised by a two-step polymerization using a number of polyethylene and propylene glycols and tolylene diisocyanate.

The successful biomedical application of SPU/collagen blends as biomaterials at some fields of medicine has been shown. These blends were used for the fabrication of artificial esophageal prostheses for treatment of injures and diseases of esophagus such as chemical burns, cicatrical structures, total stenosis in children when standard technique of surgical bypass of the nonfunctioning esophagus can not be used. The SPU/collagen blends containing anticancer agents were used for treatment of sarcoma of the orbit. It was established that the anticancer effect against Rhabdomiosarcoma of implanted blends prolongs 17-20 days and the toxic effects decrease due to reduce a total therapeutic dose from 2,0 mg/kg to 1,4 mg/kg.

Microparticles of SPU with diameter 200-500 microns were prepared with water-toluene interface emulsion polycondensation of toluene-2,4-diisocyanate and poly(ethylene glycol) of various molecular weight 400-2000. The current procedure allows to develop a series of microcapsulated drug delivery forms for respiratory therapeutic use. A method of exterior nose correction using a biocompatible SPU/collagen blend has been developed. The successful application of polyurethane films for reconstruction of the bridge and septum of nose in 15 patients was described.

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References

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1. Lelah, M.D., Cooper, S.L., Polyurethanes in Medicine, Boca Raton, CRC Press, 1986.
2. Batyrbekov, E.O., Iskakov, R.M., Boldyrev, D. Yu. Architecture and Application of Biomaterials and Biomolecular Materials. Symposium Proceedings. MRS. Warrendale, PA. USA. Vol. EXS-1.2004. 433435.
3. Batyrbekov, E., Rukhina, L., Zhubanov, B. Polymer Int. 43. 1997. 317320.
4. Iskakov, R., Batyrbekov, E., Zubanov, B.A. J. Appl. Polymer Science. 75. 2000.3543
5. Iskakov, R., Batyrbekov, E., Zhubanov, B. et al. Polymers for Advanced Technology. 9. 1998. 266270
6. Iskakov, R., Batyrbekov, E.O., Zhubanov, B.A., Mooney, D.J. Eurasian ChemTechn.J. 2004. 6. 5155.

Keywords

Segmented Polyurethane/Collagen Blends for Biomedical Application

  • Erkesh O Batyrbekov (a1), Rinat Iskakov (a2), Gulsharat Esenalina (a3), Aman Kurashev (a4), Maria Kim (a5) and Bulat Zhubanov (a6)...

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