Hostname: page-component-7bb8b95d7b-dtkg6 Total loading time: 0 Render date: 2024-09-11T20:19:05.073Z Has data issue: false hasContentIssue false
  • English
  • Français

Poly(Methacrylic Acid-g-Ethylene Glycol) Hydrogels as pH Responsive Biomedical Materials

Published online by Cambridge University Press:  15 February 2011

Cristi L. Bell  and
Nicholas A. Peppas
Cristi L. Bell
Affiliation:
School of Chemical Engineering, Purdue University, West Lafayette, IN 47907-1283
Nicholas A. Peppas
Affiliation:
School of Chemical Engineering, Purdue University, West Lafayette, IN 47907-1283
Get access

Abstract

Novel graft copolymeric, pH responsive hydrogels have been synthesized by solution polymerization. Poly(methacrylic acid-g-ethylene glycol) hydrogels exhibit reversible complexation as a function of pH because of hydrogen bonding between the PEG grafts and the PMAA main chains. These gels are being developed as pH responsive membranes for use in biomedical applications. ATR-FTIR results indicate that there is hydrogen bonding occurring in membranes swollen under conditions favorable for complexation. Equilibrium swelling studies have shown that the pH of the surrounding environment has a significant effect on the swelling behavior of these membranes. The swelling behavior has also been shown to respond rapidly to changing pH conditions. P(MAA-g-EG) membranes also show pH sensitive permeability toward solutes as a result of this environmentally sensitive swelling.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 331: Symposium T – Biomaterials for Drug and Cell Delivery , 1993 , 199
Copyright
Copyright © Materials Research Society 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Peppas, N.A., J. Bioact. Compat. Poly. 6, 241–246 (1991).Google Scholar
2. Kuhn, W., Hagarty, B., Katchalsky, A., Eisenberg, H., Nature 165, 514–516 (1959).Google Scholar
3. Katchalsky, A., Experientia, 319–320 (1949).Google Scholar
4. Tanaka, T., Polymer 20, 1404–1412 (1979).Google Scholar
5. Ohmine, I. and Tanaka, T., J. Chem. Phys. 77, 5725–5729 (1992).Google Scholar
6. Tsuchida, E. and Abe, K., Adv. Poly. Sci. 45, 1–119 (1982).Google Scholar
7. Bekturov, E. and Bimendina, L., Adv. Poly. Sci. 41, 99–147 (1981).Google Scholar
8. Osada, Y. and Takeuchi, Y., J. Polym. Sci.: Polym. Lett. Ed. 19, 303–308 (1981).Google Scholar
9. Drummond, R.K., Klier, J., Alameda, J.A., Peppas, N.A., Macromol. 22, 3816–3818 (1989).Google Scholar
10. Klier, J., Scranton, A.B., Peppas, N.A., Macromol. 23, 4944–4949 (1990).Google Scholar
11. Bae, Y.H., Okano, T., Kim, S.W., J. Contr. Rel. 9, 271–279 (1989).Google Scholar
12. Gekko, K., in Solution Properties of Polysaccharides, ACS Symposium Ser. 150, edited by Brant, D.A. (American Chemical Society, Washington D.C., 1981).Google Scholar