Skip to main content Accessibility help
×
Home

Photoembossing for Surface Texturing of Films and Fibres for Biomedical Applications

  • Nanayaa Freda Hughes-Brittain (a1), Olivier T. Picot (a1), Lin Qiu (a1), Carlos Sanchez (a2), Ton Peijs (a1) (a3) and Kees Bastiaansen (a1) (a3)...

Abstract

Photoembossing is a technique used to create relief structures using a patterned contact photo-mask exposure and a thermal development step. Typically, the photopolymer consists of a polymer binder and a monomer in a 1/1 ratio together with a photo-initiator which results in a solid and non-tacky material at room temperature. Here, new mixtures for photoembossing are presented which are potentially biocompatible. A polymer binder such as poly (methyl methacrylate) with triacrylate monomer and biocompatible photo-initiator Irgacure 369 is used. Photopolymer films produced are successfully embossed with height of relief structures controlled by UV dosage and developing temperature. Furthermore, the photopolymer blend is electrospun to form fibres with diameters of 5 μm which are then photoembossed. The photoembossed fibres showed homogenous reproducible surface textures. Biocompatibility is evaluated by culturing human umbilical vein endothelial cells (HUVECs) on films of this photopolymer blend. The study shows that photoembossing is a feasible method of producing surface texturing on both films and electrospun fibres for tissue engineering applications.

Copyright

References

Hide All
[1] Schueller, O.J.A., Duffy, D.C., Rogers, J.A., Brittain, S.T., and Whitesides, G.M., Sensors and Actuators a-Physical, vol. 78, pp. 149–159, 1999.
[2] Stutzmann, N., Friend, R.H., and Sirringhaus, H., Science, vol. 299, pp. 1881–4, 2003.
[3] Suh, K.Y., Seong, J., Khademhosseini, A., Laibinis, P.E., and Langer, R., Biomaterials, vol. 25, pp. 557–63, 2004.
[4] Walboomers, X.F. and Jansen, J.A., Odontology, vol. 89, pp. 0002–0011, 2001.
[5] Qin, D., Xia, Y., and Whitesides, G.M., Nature protocols, vol. 5, pp. 491–502, 2010.
[6] Mijatovic, D., Eijkel, J.C., and van den Berg, A., Lab on a chip, vol. 5, pp. 492–500, 2005.
[7] Tervoort, T.A., Stutzmann, N., Bastiaansen, C.W.M., Feldman, K., and Smith, P., Advanced Materials, vol. 12, pp. 557–562, 2000.
[8] Huck, W.T.S., Fichet, G., Stutzmann, N., and Muir, B.V.O., Advanced Materials, vol. 14, pp. 47–51, 2002.
[9] Mack, C., Fundamental Principles of Optical Lithography: The Science of Microfabrication: Wiley-Interscience, 2007.
[10] Sánchez, C., de Gans, B.J., Kozodaev, D., Alexeev, A., Escuti, M.J., van Heesch, C., Bel, T., Schubert, U.S., Bastiaansen, C.W.M., and Broer, D.J., Advanced Materials, vol. 17, pp. 2567–2571, 2005.
[11] de Gans, B.J., Sanchez, C., Kozodaev, D., Wouters, D., Alexeev, A., Escuti, M.J., Bastiaansen, C.W.M., Broer, D.J., and Schubert, U.S., J Comb Chem, vol. 8, pp. 228–36, 2006.
[12] Hermans, K., Tomatsu, I., Matecki, M., Sijbesma, R.P., Bastiaansen, C.W.M., and Broer, D.J., Macromolecular Chemistry and Physics, vol. 209, pp. 2094–2099, 2008.
[13] Hermans, K., Wolf, F.K., Perelaer, J., Janssen, R.A.J., Schubert, U.S., Bastiaansen, C.W.M., and Broer, D.J., Applied Physics Letters, vol. 91, 2007.

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed