Skip to main content Accessibility help

pH-dependent Gelation of Gastric Mucin


We discuss the mechanism by which gastric mucin forms a gel at low pH, which serves to protect the stomach from being damaged by the acidic gastric juice that it secretes. Frequency dependence of viscoelastic moduli of pig gastric mucin gels obtained by microscopic dynamic light scattering is presented. Atomic Force Microscopy provides direct visual evidence to indicate that mucin broken into its subunits does not gel at low pH.



Hide All
1. Monmaney, T., “Marshall's HunchNew Yorker pp. 6471, Sep. 1993.
2. Allen, A., in Physiology of the Gastrointestinal Tract, Edited by Johnson, L.R., (Raven Press, New York (1981)), 1, 617639.
3. Bhaskar, K.R., Gong, D., Bansil, R., Pajevic, S., Hamilton, J.A., Turner, B.S., LaMont, J.T., Am. J. Physiol. 261, G827–G832 (1991).
4. Cao, X., Bansil, R., Bhaskar, K.R., Turner, B.S., LaMont, J.T., Niu, N., Afdhal, N.H., Biophys. J. 76, 12501258 (1999).
5. Celli, J., Gregor, B., Turner, B., Afdhal, N. H., Bansil, R., Erramilli, S., Biomacromolecules 6(3), 13291333 (2005).
6. Hong, Z., Chasan, B., Bansil, R., Turner, B., Bhaskar, K., Afdhal, N., Biomacromolecules, 6, 34583466 (2005).
7. Bhaskar, K.R., Garik, P., Turner, B.S., Bradley, J. D., Bansil, R., Stanley, H. E., LaMont, J.T., Nature 360 (6403), 458461 (1992).
8. Waigh, T., Papagiannopoulos, A., Voice, A., Bansil, R., Unwin, A., Dewhurst, C., Turner, B.S, Afdhal, N.H., Langmuir 18(19), 71887195 (2002).
9. Bansil, R., Stanley, H.E., LaMont, J.T., Annual Review of Physiology 57, 635657 (1995).
10. Bansil, R. and Turner, B.S., Current Opinions in Colloid and Interface Science, 2005 (in press).
11. Holm, L. and Flemstrom, G., J. Int. Med. 28 (suppl), 9195 (1990).
12. Johansson, M., Synnerstad, I., Holm, L., Gastroenterology 119, 12971304 (2000).
13. Bhaskar, K.R. and Reid, L., J. Biol. Chem. 256, 75837589 (1981).
14. Kočevar-Nared, J., Kristl, J., Šmid-Korbar, J., Biomaterials 18(9), 677681 (1997).
15. Mason, T.G. and Weitz, D.A., Phys. Rev. Lett. 74, 12501253 (1995).
16. Dawson, M., Krauland, E., Wirtz, D., Hanes, J., Biotechnology Progress 20(3), 851857 (2004).
17. Sellers, L.A., Allen, A., Morris, E.R., Ross-Murphy, S.B., Biorheology 24, 615623 (1987).
18. Brayshaw, D., Berry, M., McMaster, T., Nanotechnology 15(11), 13911396 (2004).
19. McMaster, T., Berry, M., Corfield, A., Miles, M., Biophysical Journal 77(1), 533541 (1999).


pH-dependent Gelation of Gastric Mucin


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed