Hostname: page-component-76fb5796d-5g6vh Total loading time: 0 Render date: 2024-04-26T10:24:18.841Z Has data issue: false hasContentIssue false
  • English
  • Français

Osteogenesis in Cat Cranioplasty with Composite Hydroxylapatite/Plaster

Published online by Cambridge University Press:  26 February 2011

Jacob S. Hanker ,
Peggy E. Yates ,
Beverly L. Giammara ,
Charles E. Rawlings III ,
Janice Ovelmen-Levitt ,
Nicholas G. Georgiade  and
Robert F. Wilkins
Jacob S. Hanker
Affiliation:
Dental Research Center and Biomedical Engineering Curriculum, University of North Carolina, Chapel Hill, NC 27599
Peggy E. Yates
Affiliation:
Dental Research Center and Biomedical Engineering Curriculum, University of North Carolina, Chapel Hill, NC 27599
Beverly L. Giammara
Affiliation:
Analytical Electron Microscopy Laboratory, Graduate Programs and Research, University of Louisville, Louisville, KY 40292
Charles E. Rawlings III
Affiliation:
Department of Surgery, Divisions of Neurosurgery, Plastic, Reconstructive, Maxillofacial and Oral Surgery, Duke University Medical Center, Durham, NC 27710.
Janice Ovelmen-Levitt
Affiliation:
Department of Surgery, Divisions of Neurosurgery, Plastic, Reconstructive, Maxillofacial and Oral Surgery, Duke University Medical Center, Durham, NC 27710.
Nicholas G. Georgiade
Affiliation:
Department of Surgery, Divisions of Neurosurgery, Plastic, Reconstructive, Maxillofacial and Oral Surgery, Duke University Medical Center, Durham, NC 27710.
Robert F. Wilkins
Affiliation:
Department of Surgery, Divisions of Neurosurgery, Plastic, Reconstructive, Maxillofacial and Oral Surgery, Duke University Medical Center, Durham, NC 27710.
Get access

Abstract

Composite hydroxylapatite (HA)/plaster alloplasts were studied for frontal and parietal cranioplasty. The experimental defects were created in 61 anesthetized cats. They were filled with a moist 2:1 mixture of durapatite/plaster or Interpore/plaster containing 0.85% potassium sulfate. After setting, the implant site was sutured. The filled defects were very firm by physical examination and showed little particle scatter by radiography. At the time this report was prepared only 43 of the cat skulls were available for examination. After sacrifice, postmortem visual examination (VE) of the skulls suggested that new bone had formed over some implants. In most implants, however, VE could not determine whether new bone had formed between the HA particles. Probing examination (PE) of the parietal implants with a periodontal explorer gave a better indication; the presence of new bone rather than soft tissue between the HA particles was confirmed by x-ray microanalysis. The ventral surfaces (VS) of the parietal implants showed greater degrees of bone formation by PE; only 12 of 43 parietal implants showed a high degree of bone formation on the dorsal surfaces (DS) by PE whereas 34 of 43 showed this on the VS. The highly significant difference (^3X) in the amount of bone formation on the VS compared with the DS suggests that this osteogenesis, like that observed in cranial trauma, may be stimulated by the dura which acts as a periosteum by supplying blood vessels to the implant.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 239
Copyright
Copyright © Materials Research Society 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Hanker, J.S., Tucker, M.R., Terry, B.C., Carnevale, R.A. and Giammara, B.L.. Composite plaster/hydroxylapatite implants for jaw bone restoration. Mat. Res. Soc. Symp. Proc. 55, 77–96 (1986).Google Scholar
2. Rish, B.L., Dillon, J.D., Meirowsky, A.M., Caveness, W.F., Mohr, J.P., Kistler, J.P. and Weiss, G.H.. Cranioplasty: A review of 1030 cases of penetrating head injury. Neurosurgery 4, 381–385 (1979).Google Scholar
3. White, R.A., Weber, J.N. and White, E.W.. Replamineform: A new process for preparing porous ceramic, metal and polymer prosthetic materials. Science 176, 922–924 (1972).Google Scholar
4. White, E.W., Weber, J.N., Roy, D.M., Owen, E.L., Chiroff, R.T. and White, R.W.. Replamineform porous biomaterials for hard tissue implant applications. J. Biomed. Mater. Res (Symp.) 9, 23–27 (1975).Google Scholar
5. White, E.W. and Shors, E.C.. Biomaterial aspects of Interpore 200 porous hydroxylapatite. Dent. Clin. N. Amer. 30, 49–67 (1986).Google Scholar
6. Rawlings, C.E. III, Wilkins, R.H., Hanker, J.S., Georgiade, N.G. and Harrelson, J.M., J. Neurosurg. 69. 269–275 (1988).Google Scholar