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Osteoconductive HAp and TiO2 Coatings on Titanium using Hydro-process

  • Dai Yamamoto (a1), Kensuke Kuroda (a2), Ryoichi Ichino (a3) and Masazumi Okido (a4)

Abstract

Hydroxyapatite (Ca10(PO4)6(OH)2, HAp) and titanium dioxide (TiO2, titania) are of interest for bone-interfacing implant applications, because of their demonstrated osteoconductive properties. They were coated on the titanium implants using hydro-processes and investigated the in vivo performance. HAp coatings were formed on cp-titanium plates or rods by the thermal substrate method in an aqueous solution included 0.3 mM Ca(H2PO4)2 and 0.7 mM CaCl2. In the formation of carbonate apatite coating, CaHCO3 was added to the solution, and in HAp/gelatin and HAp/collagen composite coatings, acid-soluble collagen (Type I) was added. The coating experiments were conducted at 313-433 K and pH = 8 for 15 or 30 min. Titania films were formed on the titanium implants by anodizing at < 100 V in 0.1 M H2SO4, H3PO4, and NaOH aqueous solutions at 298 K. The properties for the coated samples were studied using XRD, EDX, FT-IR, and SEM. And the surface roughness of titania coatings was measured. In in vivo evaluations, the coated rod specimens were implanted in rats femoral for 2 weeks, the osteoconduction on them was evaluated. Two weeks postimplantation, new bone formed on the coated and non-coated titanium rods in the cancellous bone and cortical bone, respectively. Bone-implant contact ratio, RB-I, which was used for the evaluation of new bone formation, was significantly depended on the compound formed on titanium implants, and also the coating processes.

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Osteoconductive HAp and TiO2 Coatings on Titanium using Hydro-process

  • Dai Yamamoto (a1), Kensuke Kuroda (a2), Ryoichi Ichino (a3) and Masazumi Okido (a4)

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