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A Novel Versatile Process for the Production of Polymer Foams

Published online by Cambridge University Press:  15 February 2011

V.P. Shastri ,
I. Martin  and
R. Langer
V.P. Shastri
Affiliation:
Department of Chemical EngineeringMassachusetts Institute of Technology, Cambridge, MA 02139
I. Martin
Affiliation:
Department of Chemical EngineeringHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, email: prasha@amit.edu
R. Langer
Affiliation:
Department of Chemical EngineeringMassachusetts Institute of Technology, Cambridge, MA 02139
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Abstract

Porous polymeric media are used in several applications such as solid supports for separations and catalysis, as well as biomedical applications such as vascular grafts and wound dressings. We have developed a novel versatile process to produce polymeric cellular solids. This process which is based on a phase extraction-co-polymer precipitation is applicable to a wide range of polymer systems including water soluble polymers. It is capable of yielding polymer foams of high porosity (> 90%) and excellent mechanical characteristics in a very short time (less than 2 hours) without limitations in foam thickness. Polymer foam with such characteristics have great utility in tissue engineering applications. We have successfully explored polymer foams of biocompatible polymers produced by the presented approach for bone and cartilage engineering using bone marrow stromal cells.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 149
Copyright
Copyright © Materials Research Society 1999

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References

1. Gibson, L. & Ashby, M. Cellular solids (1997).Google Scholar
2. Szycher, M. & Lee, S. J. Biomater. Appl. 7, 142–213 (1992).Google Scholar
3. Yoda, R. J. Biomater. Sci. Polym. Ed. 9, 561–626 (1998).Google Scholar
4. Guidoin, R., couture, J., Assayed, F. & Gosselin, C. Int. Surg. 73, 241–249 (1988).Google Scholar
5. Langer, R. & Vacanti, J. Science. 260, 920 (1993).Google Scholar
6. Lu, L. & Mikos, A. MRS Bulletin. 21, 28–32 (1996).Google Scholar
7. Mikos, A.G., Thorsen, A.J., Czerwonka, L.A., Bao, Y. & Langer, R. Polymer. 35, 1068–1077 (1994).Google Scholar
8. Mooney, D.J., Baldwin, D.F., Suh, N.P., Vacanti, J.P. & Langer, Biomaterials, R.. 17, 1417–1422 (1996).Google Scholar
9. Thomson, R.C., Yaszemski, M.J., Powers, J.M. & , Mikos A.G. J. Biomat. Sci. Polym. Ed. 7, 23–38 (1995).Google Scholar
10. Wu, B.M. et al. J. Controlled Rel. 40, 77–87 (1996).Google Scholar
11. Heinrich, T., Klett, U. & Fricke, J. J. Porous Mat. 1, 7–17 (1995).Google Scholar
12. Fischer, U., Saliger, R., Bock, V., Petricevic, R. & Fricke, J. J. Porous Mat. 4, 281–285 (1997).Google Scholar
13. Martin, I. et al. in Orthopaedic Research Society (Anaheim, CA, 1999).Google Scholar
14. Schaefer, D. et al. in Orthopaedic Research Society (Anaheim, CA, 1999).Google Scholar