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Nanomonitors: Nanomaterial Based Devices Towards Clinical Immunoassays

Published online by Cambridge University Press:  01 February 2011

Shalini Prasad ,
Manish Bothara ,
Ravikiran Reddy ,
John Carruthers  and
Thomas Barrett
Shalini Prasad
Affiliation:
sprasad@pdx.edu, Portland State University, ECE, 160-11 FAB 1900 SW 4t ave, portland, OR, 97201, United States
Manish Bothara
Affiliation:
botharam@pdx.edu, Portland State Univ, Portland, OR, 97201, United States
Ravikiran Reddy
Affiliation:
rkreddy@pdx.edu, Portland State Univ, ECE, Portland, OR, 97201, United States
John Carruthers
Affiliation:
carruthe@pdx.edu, Portland State Univ, Portland, OR, 97201, United States
Thomas Barrett
Affiliation:
barreth@ohsu.edu, OHSU, Medicine, Portland, OR, 97205, United States
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Abstract

The immobilization of biomolecules on a solid substrate and their localization in “small” regions are major requirements for a variety of biomedical diagnostic applications, where rapid and accurate identification of multiple biomolecules is essential. In this specific application we have fabricated nanomitors for identifying specific protein biomarkers based on the electrical detection of antibody-antigen binding events.

The nanomonitor, lab-on-a-chip device technology is based on electrical detection of protein biomarkers. It is based on developing high density, low volume multi-well plate devices. The scientific core of this technology lies in integrating nanomaterial with micro fabricated chip platforms and exploiting the improve surface area to volume to improve the detection.

The devices that have been developed utilize electrical detection mechanisms where capacitance and conductance changes due to protein binding are used as “signatures” for biomarker profiling. In comparison to optical methods, the electrical detection technique is non-invasive as well as a label free. The signal acquisition is simple and it uses the existing data acquisition and signal analysis methods

Keywords

sensorbiomedicalnanostructure
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1095: Symposium EE – Responsive Biomaterials for Biomedical Applications , 2008 , 1095-EE06-08
Copyright
Copyright © Materials Research Society 2008

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