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Microparticles of Functionalized Polylactide Copolymers

Published online by Cambridge University Press:  10 February 2011

K. E. Gonsalves ,
S. Jin  and
M-I Baraton
K. E. Gonsalves
Affiliation:
Department of Chemistry & Polymer Program at the Institute of Materials Science University of Connecticut, Storrs, CT 06269, USA
S. Jin
Affiliation:
Department of Chemistry & Polymer Program at the Institute of Materials Science University of Connecticut, Storrs, CT 06269, USA
M-I Baraton
Affiliation:
LMCTS - ESA 6015 CNRS, University of Limoges, 123 Av. Albert Thomas, F-87060, Limoges, France
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Abstract

Microparticles of poly(lactide) (PLac) and its copolymers with the amino acids, serine (P(Lac- Ser)), and aspartic acid (P(Lac-Asp)), respectively, were synthesized using the solvent evaporation microemulsion technique. Poly(vinyl alcohol) (PVA) was added as a non-ionic surfactant to stabilize the particles. The particle sizes are in the range of 200 nm. The surface of the particles was characterized by FTIR transmission spectroscopy under evacuation at room temperature and at 200°C. Hydroxy groups originating from PVA exist on the surfaces of the particles and they were observed at 3506 cm−1. Free hydroxy groups originating from the serine residue pendant to the copolymer P(Lac-Ser) backbone were observed at 3396 cm−1. Also, free carboxylic acid groups pendant to the copolymer P(Lac-Asp) backbone, originating from the aspartic acid residue, were observed at 3387 cm−1. The appearance of the free hydroxy or carboxylic acid groups in the IR spectra also showed that these hydrophilic functional groups moved to the surface of the particles in the process of microemulsion.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 501: Symposium FF – Surface Controlled Nanoscale Materials for High-Added… , 1997 , 233
Copyright
Copyright © Materials Research Society 1998

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References

REFERENCES

1. Domb, A. J., Amselem, S. and Maniar, M. in Polymeric Materials edited by Dumitriu, S. (Marcel Dekker, Inc., New York, 1993), p399 Google Scholar
2. Lewis, D. H., in Biodegradable Polymers as Drug Delivery Systems, edited by Chasin, M. and Langer, R. (Marcel Dekker, Inc., New York, 1990), p. 1 Google Scholar
3. Barrera, D. A., Zylstra, E. P., Lansbury, T. and Langer, R., J. Am. Chem. Soc., 115, 11010 (1993).Google Scholar
4. Hrkach, J. S., Ou, J., Lotan, N. and Langer, R., Macromolecules, 28, 4736 (1995).Google Scholar
5. Veld, P. J. A. In't, Dijkstra, P. J. and Feijen, J., Makromol. Chem., 193, 2713 (1992).Google Scholar
6. Arndd, S. C. and Lenz, R. W., Makromol. Chem. Macromol. Symp., 61, 285 (1986).Google Scholar
7. Caron, A., Braud, C., Bunel, C. and Vert, M., Polymer, 31, 1797 (1990).Google Scholar
8. Gelbin, M. E. and Kohn, J., J. Am. Chem. Soc., 114, 3962 (1992).Google Scholar
9. Fieter, J., Borgne, A. L. and Spassky, N., Polym. Bull, 24, 348 (1990).Google Scholar
10. Jin, S. and Gonsalves, K. E., Polymer, in press.Google Scholar
11. Scholes, P.D., Coombes, A. G. A., Illum, L., Davis, S. S., Vert, M. and Davies, M. C., J. Contr. Rel., 25, 145 (1993).Google Scholar
12. Niwa, T., Takeuchi, H., Hino, T., Kunou, N. and Kawashima, Y., J. Contr. Rel., 25, 89 (1993).Google Scholar
13. Nrannon-Peppas, L., Intern. J. Pharma., 116, 1 (1995).Google Scholar
14. Couvreur, P., Dubernet, C. and Puisieux, F., Eur. J. Pharm. Biopharm., 41, 1 (1995).Google Scholar
15. Planten, S. and Saltzman, W. M., TRIP, 4(6), 177 (1996).Google Scholar