Hostname: page-component-76fb5796d-vfjqv Total loading time: 0 Render date: 2024-04-26T18:46:20.960Z Has data issue: false hasContentIssue false
  • English
  • Français

Mechanics of Collagen in the Human Bone: Role of Collagen-Hydroxyapatite Interactions

Published online by Cambridge University Press:  01 February 2011

Kalpana S Katti ,
Shashindra Man Pradhan  and
Dinesh R Katti
Kalpana S Katti
Affiliation:
kalpana.katti@ndsu.eduNorth Dakota State Universitycivil engineering, Fargo, North Dakota, United States
Shashindra Man Pradhan
Affiliation:
shashindra.pradhan@ndsu.eduNorth Dakota State Universitycivil engineering, Fargo, North Dakota, United States
Dinesh R Katti
Affiliation:
dinesh.katti@ndsu.eduNorth Dakota State Universitycivil engineering, Fargo, North Dakota, United States
Get access

Abstract

Here, we report results of our simulations studies on modeling the collagen-hydroxyapatite (HAP) interface in bone and influence of these interactions on mechanical behavior of collagen through molecular dynamics and steered molecular dynamics (SMD). Models of hexagonal HAP (10-10) and (0001) surface, and collagen with and without telopeptides were built to investigate the mechanical response of collagen in the proximity of mineral. The collagen molecule was pulled normal and parallel to the (0001) surface of hydroxyapatite. Water molecules were found have an important impact on deformation behavior of collagen in the proximity of HAP due to their large interaction energy with both collagen and HAP. Collagen appears stiffer at small displacement when pulled normal to HAP surface. At large displacement, collagen pulled parallel to HAP surface is stiffer. This difference in mechanical response of collagen pulled in parallel and perpendicular direction results from a difference in deformation mechanism of collagen. Further, the collagen molecule pulled in the proximity of HAP, parallel to surface, showed marked improvement in stiffness compared to absence of HAP. Furthermore, the deformation behavior of collagen not only depends on the presence or absence of HAP and direction of pulling, but also on the type of mineral surface in the proximity. The collagen pulled parallel to (10-10) and (0001) surfaces showed characteristically different type of load-displacement response. In addition, here we also report simulations on 300 nm length of collagen molecule indicating the role of length of model on the observed response in terms of both the magnitude of modulus obtained as well as the mechanisms of response of collagen to loading.

Keywords

bonebiomedicalnanoscale
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1274: Symposium QQ – Biological Materials and Structures in Physiologically Extreme Conditions and Disease , 2010 , 1274-QQ06-03
Copyright
Copyright © Materials Research Society 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Eastoe, J. E. and Eastoe, B. Biochem. J. 57, 453 (1954).Google Scholar
2 Termine, J. D. Wuthier, R. E. and Posner, A. S. Proc Soc Exp Biol Med 125, 4 (1967).Google Scholar
3 Currey, J. D. Zioupos, P. Davies, P. and Casino, A. Proc Biol Sci 268, 107 (2001).Google Scholar
4 Landis, W. J. Song, M. J. Leith, A. McEwen, L. and McEwen, B. F. J Struct Biol 110, 39 (1993).Google Scholar
5 Uzel, S. Buehler, M. J. Integrative Biology 1, 7 (2009).Google Scholar
6 Katti, D.R., Pradhan, S.M., and Katti, K.S., Journal of Biomechanics 43, 9 (2010).Google Scholar
7 Malone, J. P. George, A. and Veis, A. Proteins: Struct, Funct, BIoinf 54, 206 (2004).Google Scholar
8 Jones, E. Y. and Miller, A. Biopolymers 26, 463 (1987).Google Scholar
9 Otter, A. Kotovych, G. and Scott, P. G. Biochemistry 28, 8003 (1989).Google Scholar
10 Sudarsanan, K. and Young, R. A. Acta Crystallogr., Sect. B 25, 1534 (1969).Google Scholar
11 Bhowmik, R. Katti, K. S. and Katti, D. Polymer 48, 664 (2007).Google Scholar
12 Bhowmik, R. Katti, K. S. and Katti, D. R. J. Mater. Sci. 42, 8795 (2007).Google Scholar
13 Bhowmik, R. Katti, K. S. Katti, D. R. International J. Nanotech. 6, 511 (2009).Google Scholar
14 Bhowmik, R. K.Katti, S. Katti, D. R. J. Engineering Mechanics-ASCE, 135, 413 (2009).Google Scholar
15 Bhowmik, R. K.Katti, S. Katti, D. R. J. Nanosci. Nanotech. 8, 2075 (2009).Google Scholar
16 Humphrey, W. Dalke, A. and Schulten, K. J. Molec. Graphics 14 1 (1996).Google Scholar