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In-Vivo Assessment of Tissue Compatibility and Calcification of Bulk and Porous Silicon

  • A P Bowditch (a1), K Waters (a1), H Gale (a1), P Rice (a1), E A M Scott (a1), L T Canham (a2), C L Reeves (a2), A Loni (a2) and T I Cox. (a2)...


The compatibility of both bulk and porous silicon at the subcutaneous site has been assessed for the first time, following ISO standard procedures. The in-vivo responses to implantation were monitored in the guinea pig and histopathological reactions evaluated at 1, 4, 12 and 26 weeks. Attention is focused here on the histological assessment protocols used, and the results demonstrating in-vivo evidence for good tissue compatibility, and porous Si bioactivity with regards calcification.



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[1] Canham, L T. Adv Mater 7, 1033 (1995).
[2] Black, J in Biological Performance of Materials - Fundamentals of Biocompatibility. 2nd Edition. Marcel Dekker Inc (1992).
[3] Stensas, S S, Stensas., L J Acta Neuropathologica 41, 145155 (1978).
[4] Edell, D J Toi, V V McNeill, V M Clark, L D. IEEE Trans BME 39, 635 (1992).
[5] Schmitt, S Horch, K Normann., R Biomed, J Mater Res 27, 1393 (1993).
[6] Desai, T Ferrari, M Mazzoni., G Trans ASME Vol PD-71, p97101 (1995).
[7] Biological Evaluation of Medical Devices. Part 6 - Tests for Local Effects after Implantation. ISO standard 10993-6 (1994).
[8] Bowditch, A P et al. Biocompatibility of bulk and porous silicon at a subcutaneous site in the guinea pig. To be published.
[9] Canham, L T Reeves, C L in Thin Films and Surfaces for Bioactivity and Biomedical Applications edited by Cotell, C M et al MRS Proc Vol.414, 189194 (1996).
[10] Canham, L Tet al. Adv Mater 8, 847 (1996).
[11] Andersson, O H et al in Bioceramics, Vol 7, p6 7 -72 (1994).
[12] Yang, Z Yuan, H, Tong, W Zhou, P, Chen, W Zhang, X,.Biomaterials 17, 2131 (1996).
[13] Canham, L T et al in Advances in Microcrystalline and Nanocrystalline Semiconductors-1996. Edited by Collins, R W et al. MRS Proc Vol 452, p579590 (1997).


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