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The Influence of Intracellular Transport Developmenttransport on Axonal Development

Published online by Cambridge University Press:  15 February 2011

H.G.E. Hentschel  and
A. Fine
H.G.E. Hentschel
Affiliation:
Department of Physics, Emory University, Atlanta GA 30322, USA, phshgeh@physics.emory.edu
A. Fine
Affiliation:
Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
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Abstract

We describe how axonal differentiation during neuronal growth is dependent on intracellular transport. The interaction of diffusion and active transport of a morphogen whose concentration at the neurite tips influences the growth rate can lead to an instability involving winner-take-all growth, forming a single, quickly growing neurite (the axon) and inhibiting the growth of the other neurites. We discuss the dynamics of this process and its dependence on cell parameters.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 489: Symposium K – Materials Science of the Cell , 1997 , 181
Copyright
Copyright © Materials Research Society 1998

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