Hostname: page-component-848d4c4894-8kt4b Total loading time: 0 Render date: 2024-06-22T02:08:45.030Z Has data issue: false hasContentIssue false
  • English
  • Français

Imaging of gold dendrimer nanocomposites in cells

Published online by Cambridge University Press:  21 March 2011

Jonathan D. Eichman ,
Mohamed K. Khan ,
Inhan Lee ,
James R. Baker Jr ,
Theodore S. Lawrence ,
Dorothy R. Sorenson ,
Chris A. Edwards  and
Lajos Balogh
Jonathan D. Eichman
Affiliation:
Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI 48109-0533
Mohamed K. Khan
Affiliation:
Department of Cell & Development Biology, University of Michigan, Ann Arbor, MI 48109-0533
Inhan Lee
Affiliation:
Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI 48109-0533
James R. Baker Jr
Affiliation:
Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI 48109-0533
Theodore S. Lawrence
Affiliation:
Department of Cell & Development Biology, University of Michigan, Ann Arbor, MI 48109-0533
Dorothy R. Sorenson
Affiliation:
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109-0533
Chris A. Edwards
Affiliation:
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109-0533
Lajos Balogh
Affiliation:
Department of Cell & Development Biology, University of Michigan, Ann Arbor, MI 48109-0533 Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109-0533
Get access

Abstract

Dendrimer nanocomposites (DNC) are hybrid nanoparticles formed by the dispersion and immobilization of guest atoms or small clusters in dendrimer matrices. They have a great potential in biomedical applications due to their controlled composition, predetermined size, shape and surface functionalities. In this work, nanocomposites of gold and poly(amidoamine) dendrimers {Au(0)n-PAMAM} have been selected to demonstrate this nanoparticle based concept. {Au(0)n-PAMAM} gold dendrimer nanocomposites with a well-defined size have been synthesized and imaged by TEM both in vitro and in vivo. Dendrimer nanocomposites have also the potential to be used as drug delivery vehicles either utilizing bioactive guests or incorporating radioactive isotopes. Radioactive dendrimer nanocomposites, e.g. {198-Au}, can be delivered to the tumor either by means of injecting the active nanoparticles directly into the tumor microvasculature or by intravenous injection. Both specific or non-specific targeting can be utilized in this process to achieve appropriate transfer.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 676: Symposium Y – Synthesis, Functional Properties and Applications of Nanostructures , 2001 , Y9.3
Copyright
Copyright © Materials Research Society 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Tomalia, D. A.; Dewald, J. R.; Hall, M. J.; Martin, S. J.; Smith, P. B. First SPSJ Int. Polym. Conference, Kyoto, Japan, August 1984, 65 Google Scholar
2. Tomalia, D. A.; Baker, H.; Dewald, J.; Hall, M.; Kallos, M.; Martin, S.; Roeck, J.; Ryder, J.; Smith, P. Polym. J. (Tokyo) 1985, 17, 117–132.Google Scholar
3. Newkome, G. R.; Yao, Z-Q; Baker, G. R.; Gupta, V. K., J.Org. Chem. 1985, 50, 2003.Google Scholar
4. Hawker, C. J.; Frechet, J. M. J., J. Am. Chem. Soc. 1990, 112, 7638.Google Scholar
5. Tomalia, D. A.; Dvornic, P., Polymeric Materials Encyclopedia, Ed.: Salamone, J. C., 1996, Volume 3, D-E, CRC Press, 1814.Google Scholar
6. Tomalia, D. A., Naylor, A. M.; Goddard, W. A. III, Angew. Chem. Int. Ed. Engl. 1990, 29, 138.Google Scholar
7. de Gennes, P. G.; Hervet, H., J. de Physique Lett. (Paris) 1983, 44, 9, 351.Google Scholar
8. Mansfield, M. L.; Klushin, L. I., Macromolecules 1993, 26, 4262.Google Scholar
9. Bhalgat, , Mahesh, K.; Roberts, , Jeanette, C., Eur. Polym. J. 2000, 36(3), 647–651.Google Scholar
10. Balogh, Lajos, Swanson, D. R., Spindler, R. and Tomalia, D. A.: Formation and Characterization of Dendrimer-Based Water Soluble Inorganic Nanocomposites; Proceedings of ACS PMSE, 1997 (77), 118.Google Scholar
11. Nora Beck Tan, Balogh, L. and Trevino, S.: Structure of Metallo-Organic Nanocomposites Produced from Dendrimer Complexes; Proceedings of ACS PMSE, 1997 (77), 120.Google Scholar
12. Esumi, K., Suzuki, A., Aihara, N., Usui, K., Torigoe, K., Langmuir 1998,14(12), 3157.Google Scholar
13. Balogh, L., Valluzzi, R., Laverdure, K. S., Gido, S. P.; Hagnauer, G. L., Tomalia, D. A., J. Nanopart. Res. 1999, 1(3), 353.Google Scholar
14. Garcia, M. E., Baker, L. A., Crooks, R. M., Anal. Chem., 1999, 71, 256.Google Scholar
15. Esumi, K., Suzuki, A., Yamahira, A., Torigoe, K., Langmuir, 2000, 16, 2604.Google Scholar
16. Gr hn, F., Bauer, B. J., Akpalu, Y. A., Jackson, C. L., Amis Eric, J., Macromolecules 2000, 33(16), 6042.Google Scholar
17. He, J.-A., Valluzzi, R., Yang, K., Dolukhanyan, T., Sung, C. M., Kumar, J., Tripathy, S. K., Samuelson, L., Balogh, L., Tomalia, D. A., Chem. Mater. 1999, 11, 3268.Google Scholar
18. Wu, C.; Brechbiel, M. W.; Kozak, R. W.; Gansow, O. A. Bioorganic & Medicinal Chemistry Letters, 1994, 4(3), 449.Google Scholar
19. Margerum, L. D.; Campion, B. K.; Koo, M.; Shargill, N.; Lai, J.; Marumoto, A.; Sontum, P. C. J. Alloys Compd. 1997, 249 (1-2), 185.Google Scholar
20. Kim, Yoonkyung; Zimmerman Steven, C. Curr. Opin. Chem. Biol. 1998, 2(6), 733–742 Google Scholar
21. Kobayashi, H., Sato, N., Kawamoto, S., Saga, T., Hiraga, A., Haque, T. L., Ishimori, T., Konishi, J., Togashi, K., Brechbiel, M. W., Bioconjugate Chem. 2001, 12, 100–107 Google Scholar
22. Bielinska, A.; Kukowska-Latallo, J. F.; Johnson, J.; Tomalia, D. A.; Baker, J. R. Jr. Nucleic Acids Res., 1996, 24, 2176.Google Scholar
23. Kukowska-Latallo, J. F.; Bielinska, A. U.; Johnson, J.; Spindler, R.; Tomalia, D. A.; Baker, J. R. Jr. Proc. Natl. Acad. Sci. 1996, 93, 4897.Google Scholar
24. Qin, L.; Pahud, D. R.; Ding, Y.; Bielinska, A. U.; Kukowska-Latallo, J. F.; Baker, J. R. Jr.; Bromberg, J. S. Hum. Gene Ther. 1998, 9(4), 553–560 Google Scholar
25. Bielinska, A. U.; Kukowska-Latallo, J. F.; Baker, J. R. Jr. Biochim. Biophys. Acta 1997, 1353, 2, 180.Google Scholar
26. Bielinska, Anna U.; Chen, Chunling; Johnson, Jennifer; Baker James, R. Jr. Bioconjugate Chem 1999, 10, 843–850 Google Scholar
27. Ottaviani, M. F.; Sacchi, B.; Turro, N. J.; Chen, W.; Jockusch, S.; Tomalia, D. A. Macromolecules, 1999, 32, 2275.Google Scholar
28. Chen, W., Turro, N‥J., Tomalia, D.A., Langmuir, 2000, 16, 15.Google Scholar
29. Balogh, L., Swanson, D. R., Tomalia, D. A., Hagnauer, G. L., McManus, A. T., Nano Letters, 2001, 1(1) 18–21 Google Scholar
30. Jackson Catheryn, L.; Chanzy Henri, D.; Booy Frank, P.; Drake Bartholomew, J.; Tomalia Donald, A.; Bauer Barry, J.; Amis Eric, J., Macromolecules 1998, 31, 6259–6265.Google Scholar
31. Balogh, L., Bielinska, A., Eichman, J. D., Lee, I., Baker, J. R. Jr., PNAS, in manuscriptGoogle Scholar