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Enhancing the Biological Stability and Functionalities of Quantum Dots via Compact Multifunctional Ligands

Published online by Cambridge University Press:  01 February 2011

Kimihiro Susumu ,
Thomas Pons ,
Igor L. Medintz  and
Hedi Mattoussi
Kimihiro Susumu
Affiliation:
susumu@ccs.nrl.navy.mil, U.S. Naval Research Laboratory, Division of Optical Sciences, 4555 Overlook Avenue, SW, Washington, DC, 20375, United States
Thomas Pons
Affiliation:
thomas.pons@gmail.com, U.S. Naval Research Laboratory, Division of Optical Sciences, 4555 Overlook Avenue, SW, Washington, DC, 20375, United States
Igor L. Medintz
Affiliation:
igor.medintz@nrl.navy.mil, U.S. Naval Research Laboratory, Center for Bio/Molecular Science and Engineering, 4555 Overlook Avenue, SW, Washington, DC, 20375, United States
Hedi Mattoussi
Affiliation:
hedi.mattoussi@nrl.navy.mil, US Naval Research Laboratory, Optical Sciences Division, Code 5611, 4555 Overlook Avenue, SW, Washington, DC, 20375, United States, 202-767-9473, 202-404-8114
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Abstract

Format

This is a copy of the slides presented at the meeting but not formally written up for the volume.

Abstract

We have designed and synthesized a series of modular ligands based on poly(ethylene glycol) (PEG) coupled with functional terminal groups to promote biocompatibility of water-soluble quantum dots (QDs). Each hydrophilic ligand is comprised of three modules: a PEG single chain to promote hydrophilicity, dihydrolipoic acid (DHLA) unit connected to one end of the PEG chain for strong anchoring on the QD surface, and potential biological functional groups (biotin, amino, and carboxyl groups) at the other end of the PEG. Water-soluble QDs capped with one type or mixtures of the functional ligands were prepared via cap exchange with the native hydrophobic caps. Homogeneous QD solutions that are stable over extended periods of time and over broad pH range were prepared. Surface binding assay showed that DHLA-PEG-biotin-functionalized QDs strongly interacted with NeutrAvidin-modified surfaces. The new functional surface ligands studied here provide not only stable and highly water-soluble QDs but also simple and easy access to various biological entities.

Keywords

biomaterialchemical synthesisnanostructure
Type
Slide Presentations
Information
MRS Online Proceedings Library (OPL) , Volume 1019: Symposium FF – Engineered Nanoscale Materials for the Diagnosis and Treatment of Disease , 2007 , 1019-FF08-10
Copyright
Copyright © Materials Research Society 2007

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