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Electrical Detection of Deoxyribonucleic Acid Hybridization With AlGaN/GaN High Electron Mobility Transistors

Published online by Cambridge University Press:  01 February 2011

ByoungSam Kang ,
S. J. Pearton ,
J. J. Chen ,
F. Ren ,
J. W. Johnson ,
R. J. Therrien ,
P. Rajagopal ,
J. C. Roberts ,
E. L. Piner  and
K. J. Linthicum
ByoungSam Kang
Affiliation:
bskang@che.ufl.edu, University of Florida, Chemical Engineering, University of Florida Chemical Eng., Bldg. #723 Rm. #119, Gainesville, FL, 32611, United States, 352-846-2989, 352-392-9513
S. J. Pearton
Affiliation:
spear@mse.ufl.edu, University of Florida, Materials Science and Engineering, Gainesville, FL, 32611, United States
J. J. Chen
Affiliation:
jjchen@che.ufl.edu, University of Florida, Chemical Engineering, Gainesville, FL, 32611, United States
F. Ren
Affiliation:
fren@che.ufl.edu, University of Florida, Chemical Engineering, Gainesville, FL, 32611, United States
J. W. Johnson
Affiliation:
wjohnson@nitronex.com, Nitronex Corporation, Raleigh, NC, 27606, United States
R. J. Therrien
Affiliation:
wjohnson@nitronex.com, Nitronex Corporation, Raleigh, NC, 27606, United States
P. Rajagopal
Affiliation:
wjjohnson@nitronex.com, Nitronex Corporation, Raleigh, NC, 27606, United States
J. C. Roberts
Affiliation:
wjjohnson@nitronex.com, Nitronex Corporation, Raleigh, NC, 27606, United States
E. L. Piner
Affiliation:
wjjohnson@nitronex.com, Nitronex Corporation, Raleigh, NC, 27606, United State s
K. J. Linthicum
Affiliation:
wjjohnson@nitronex.com, Nitronex Corporation, Raleigh, NC, 27606, United States
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Abstract

Au-gated AlGaN/GaN High Electron Mobility Transistor (HEMT) structures were functionalized in the gate region with label free 3′-thiol modified oligonucleotides. This serves as a binding layer to the AlGaN surface for hybridization of matched target Deoxyribonucleic Acid (DNA). X-ray photoelectron spectroscopy (XPS) shows that immobilization of thiol modified DNA covalently bonded with gold on the gated region. Hybridization between probe DNA and matched or mismatched target DNA on the Au-gated HEMT was detected by electrical measurements. The HEMT drain-source current showed a clear decrease of 115 μA as this matched target DNA was introduced to the probe DNA on the surface, showing the promise of the DNA sequence detection approach for biological sensing.

Keywords

biomaterialsensorx-ray photoelectron spectroscopy (XPS)
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 955: Symposium I – Advances in III-V Nitride Semiconductor Materials and Devices , 2006 , 0955-I14-06
Copyright
Copyright © Materials Research Society 2007

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