Hostname: page-component-8448b6f56d-gtxcr Total loading time: 0 Render date: 2024-04-25T06:21:09.729Z Has data issue: false hasContentIssue false
  • English
  • Français

The Effect of Varying Percentages of Fluosol-Da Hemodilution on Antipyrine Metabolism in the Rat

Published online by Cambridge University Press:  26 February 2011

Robert P. Shrewsbury ,
Sharon R. Oliver ,
Wanda T. Anderson ,
Lee M. Lewis  and
Lisa G. White
Robert P. Shrewsbury
Affiliation:
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360
Sharon R. Oliver
Affiliation:
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360
Wanda T. Anderson
Affiliation:
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360
Lee M. Lewis
Affiliation:
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360
Lisa G. White
Affiliation:
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360
Get access

Abstract

Antipyrine disposition and metabolism in conscious, unrestrained Sprague-Dawley rats after 25% or 50% Fluosol hemodilution is reported. 25% hemodilution depressed antipyrine metabolism for 24 hours by primarily inhibiting cytochrome P-450. However, 50% hemodilution produced significant increases in the cytochrome P-450 activity after 48 hours. 25% hemodilution significantly reduced the antipyrine Vd at 0.5 and 72 hours. After 50% hemodilution, the Vd alternated between values greater and less than control throughout the 72hour study.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 147
Copyright
Copyright © Materials Research Society 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Mitsuno, T., Ohyanagi, H., Yokoyama, K., Artif. Organs 8, 25 (1984).CrossRefGoogle Scholar
2. Bizot, W.B. and Rink, R.D., Experientia 41, 1127 (1985).CrossRefGoogle Scholar
3. Kemner, J.M., Snodgrass, W.R., Worley, S.E., Hodges, G.R., Clark, G.M., Hignite, C.E., J. Lab. Clin. Med. 104, 433 (1984).Google Scholar
4. Wilson, V.L., Larson, R.E., Moldowan, M.J., Chem.-Biol. Interactions 40, 159 (1982).CrossRefGoogle Scholar
5. Shrewsbury, R.P., White, S.G., Pollack, G.M., Wargin, W.A., J. Pharm. Pharmacol. 38, 883 (1986).CrossRefGoogle Scholar
6. Danhof, M., Vis, E. de Groot-van der, Breimer, D.D., Pharmacol. 18, 210 (1979).CrossRefGoogle Scholar
7. Griffeth, L.K., Rosen, G.M., Rauckman, E.J., Drug Metab. Dispos. 12, 588 (1984).Google Scholar
8. Yokoyama, K., Watanabe, M., Naito, R., in Oxygen Carrying Colloidal Blood Substitutes: Fifth International Symposium on Perfluorochemical Blood Substitutes, edited by Frey, R., Beisbarth, H., Stosseck, H. (W. Zuckschwerdt Verlag, Munchen, 1982), pp. 214–219.Google Scholar
9. Teunissen, M.W.E., Torren, J.E. Meerburg-van der, Vermeulen, N.P.E., Breimer, D.D., J. Chromat. 278, 367 (1983).CrossRefGoogle Scholar
10. Lowe, K.C. and Bollands, A.D., Med. Lab. Sci. 42, 367 (1985).Google Scholar
11. Willcox, M.L., Newman, M.M., Paton, B.C., J. Surg. Res. 25, 349 (1978).CrossRefGoogle Scholar
12. Geyer, R.P., in Oxygen Carrying Colloidal Blood Substitutes: Fifth International Symposium on Perfluorochemical Blood Substitutes, edited by Frey, R., Beisbarth, H., Stosseck, H. (W. Zuckschwerdt Verlag, Munchen, 1982), pp. 19–29.Google Scholar
13. Oie, S. and Benet, L.Z., Ann. Reports Med. Chem. 15, 277 (1980).CrossRefGoogle Scholar
14. Lutz, J., Metzenauer, P., Kunz, E., Heine, W.D., in Oxygen Carrying Colloidal Blood Substitutes: Fifth International Symposium on Perfluorochemical Blood Substitutes, edited by Frey, R., Beisbarth, H., Stosseck, H. (W. Zuckschwerdt Verlag, Munchen, 1982), pp. 73–81.Google Scholar
15. Kessler, M. and Messmer, K., in Intentional Hemodilution, edited by Messmer, K. and Schmid-Schonbein, H. (Karger, Basel, 1975), pp. 16–33.Google Scholar
16. Kessler, M., Vogel, H., Gunther, H., Harrison, D.K., Hoper, J., in Advances in Blood Substitutes Research: Progress in Clinical and Biological Research, edited by Bolin, R.B., Geyer, R.P., Nemo, G.J. (Alan R. Liss, New York, 1983), pp. 237–248.Google Scholar
17. Ohyanagi, H., Matsui, E., Saitoh, Y., Hagihara, B., in Advances in Blood Substitutes Research: Progress in Clinical and Biological Research, edited by Bolin, R.B., Geyer, R.P., Nemo, G.J. (Alan R. Liss, New York, 1983), p. 448.Google Scholar
18. Stevenson, I.H. Br. J. Clin. Pharmacol. 4, 261 (1977).CrossRefGoogle Scholar
19. Watanabe, M., Hanada, S., Yano, K., Yokoyama, K., Suyama, T., Naito, R., in Proceedings of the Fourth International Symposium on Perfluorochemical Blood Substitutes, edited by R. Naito (Excerpta Medica, Amsterdam, 1979), pp. 347–358.Google Scholar
20. Matsumoto, T., Watanabe, M., Hamano, T., Hanada, S., Suyama, T., Naito, R., Chem. Pharm. Bull. 25, 2163 (1977).CrossRefGoogle Scholar
21. Fournier, G., Barrois, V., Girard, C., Robert, D., Foulletier, L., Experientia 36, 568 (1980).CrossRefGoogle Scholar
22. Gibaldi, M., McNamara, P.J., Eur. J. Clin. Pharmacol. 13, 373 (1978).CrossRefGoogle Scholar