Hostname: page-component-8448b6f56d-gtxcr Total loading time: 0 Render date: 2024-04-23T10:56:59.475Z Has data issue: false hasContentIssue false
  • English
  • Français

CPT Encapsulated Silica-titania Hollow Nanoparticle Targeting SK-BR-3 Cells for efficient Anticancer treatment

Published online by Cambridge University Press:  24 February 2015

Yoonsun Jang  and
Jyongsik Jang
Yoonsun Jang*
Affiliation:
Chemical Convergence for Energy & Environment (C2E2,) School of Chemical and Biological Engineering, College of Engineering, Seoul National University (SNU), Seoul, Korea.
Jyongsik Jang*
Affiliation:
Chemical Convergence for Energy & Environment (C2E2,) School of Chemical and Biological Engineering, College of Engineering, Seoul National University (SNU), Seoul, Korea.
*
*Email: ysjang88@snu.ac.kr
Get access

Abstract

HER-conjugated hollow nanoparticles (HER–HNP, ca. 50 nm in diameter) are fabricated using a dissolution and re-deposition method and used to encapsulate camptothecin (CPT). The HER-HNP-CPT is used as an anti-cancer agent for human breast cancer SK-BR-3. It has excellent mono-dispersity and a high loading efficiency for CPT. Two kind of cell lines are used in this study; SK-BR-3 and RAW 264.7. SK-BR-3 and RAW 264.7 are used as targeting and controlling cell line, respectively. When SK-BR-3 cells are treated with HER-HNP-CPT, the viability decreased to 55%, which is ca. 1.5 times higher anti-cancer efficiency in comparison to RAW 264.7. The HER-HNP-CPT system offers a new opportunity to facilitate implementation of a hydrophobic drug for effective anti-cancer treatment of SK-BR-3 cells.

Keywords

biomedicalnanostructurenanoscale
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1725: Symposium I – Emerging 1D and 2D Nanomaterials in Health Care , 2015 , mrsf14-1725-i07-07
Copyright
Copyright © Materials Research Society 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Cheng, K., Rahier, N. J., Eisenhauer, B. M., Gao, R., Thomas, S. J., Hecht, S. M., Am, J.. Chem. Soc. 127, 838 (2005)CrossRefGoogle Scholar
Sriram, D., Yogeeswari, P., Thirumurugan, R., Bal, T. R., Nat. Prod. Res. 19, 393 (2005)CrossRefGoogle Scholar
Zhao, N., You, J., Zeng, Z., Li, C., Zu, Y., Small 9, 3477 (2013)CrossRefGoogle Scholar
Oh, W. K., Kim, S., Choi, M., Kim, C., Jeong, Y. S., Cho, B. R., Hahn, J. S. and Jang, J., ACS nano 4, 5301 (2010)CrossRefGoogle Scholar
Chen, Z. H., Kim, C., Zeng, X.-b., Hwang, S. H., Jang, J., Ungar, G., Langmuir 28, 15350 (2012)CrossRefGoogle Scholar
Stçber, W., Fink, A., Bohn, E., J. Colloid Interface Sci. 26, 62 (1968)CrossRefGoogle Scholar
Bogush, G., Tracy, M. and Zukoski, C., J. Non-Cryst. Solids 104, 95 (1988)CrossRefGoogle Scholar
Lu, J., Liong, M., Zink, J. I., Tamanoi, F., Small 3, 1341 (2007)CrossRefGoogle Scholar