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Blood Compatibility of Stainless-Steel and Titanium Immobilized with Alginic Acid Layers

Published online by Cambridge University Press:  11 February 2011

Tomohiko Yoshioka ,
Kanji Tsuru ,
Satoshi Hayakawa  and
Akiyoshi Osaka
Tomohiko Yoshioka
Affiliation:
Biomaterials Laboratory, Faculty of Engineering, Okayama University Tsushima, Okayama, 700–8530, Japan.
Kanji Tsuru
Affiliation:
Biomaterials Laboratory, Faculty of Engineering, Okayama University Tsushima, Okayama, 700–8530, Japan.
Satoshi Hayakawa
Affiliation:
Biomaterials Laboratory, Faculty of Engineering, Okayama University Tsushima, Okayama, 700–8530, Japan.
Akiyoshi Osaka
Affiliation:
Biomaterials Laboratory, Faculty of Engineering, Okayama University Tsushima, Okayama, 700–8530, Japan.
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Abstract

γ-Aminopropyltriethoxysilane (γ-APS) was grafted on stainless-steel and titanium substrates, and subsequently alginic acid layer was immobilized on them. Their surfaces were characterized with X-ray photoelectron spectroscopy (XPS) and contact angle measurement. Blood compatibility of thus obtained substrates was evaluated in terms of both the number of the adhered platelets and blood clotting factors for plasma contacted with the substrates such as active partial thromboplastin time (PTT), prothrombin time (PT), and amount of fibrinogen (Fib). The steel and titanium substrates with alginic acid layer did not affect blood clotting factors. In vitro platelet adhesion assay indicated that those substrates adhered less number of platelets than non-treated substrates. Hence the alginic acid immobilization leads to blood compatible surfaces.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 734: Symposia A/B – Defect-Mediated Phenomena in Ordered Polymers – Polymer/Metal Interfaces and Defect Mediated Phenomena in Ordered Polymers , 2002 , B9.48
Copyright
Copyright © Materials Research Society 2003

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References

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