Hostname: page-component-7bb8b95d7b-cx56b Total loading time: 0 Render date: 2024-09-11T20:51:59.725Z Has data issue: false hasContentIssue false
  • English
  • Français

Biomimetic Preparation of ha Precursors at 37°C in Urea- and Enzyme Urease-Containing Synthetic Body Fluids

Published online by Cambridge University Press:  10 February 2011

D Bayraktar  and
A C. Tas
D Bayraktar
Affiliation:
Dept. Metal & Mat. Eng., Middle East Technical University, Ankara 06531, Turkey
A C. Tas
Affiliation:
Pulvermetall. Lab., Max-Planck-Institute, Stuttgart D-70569, Germany
Get access

Abstract

An important inorganic phase of synthetic bone applications, calcium hydroxyapatite (HA, Ca10(PO4)6(OH)2), was prepared as a single-phase and sub-micron bioceramic powder. Carbonated HA precursors were synthesized from calcium nitrate tetrahydrate and diammonium hydrogen phosphate salts dissolved in “synthetic body fluid” (SBF) solutions, containing urea (H2NCONH2) and enzyme urease, under the biomimetic conditions of 37°C and pH 7.4, by using a novel chemical precipitation technique.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 599: Symposium DD – Mineralization in Natural & Synthetic Biomaterials , 1999 , 159
Copyright
Copyright © Materials Research Society 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Hench, L. L. and Wilson, J., An Introduction to Bioceramics, World Scientific, London, 1993, pp. 8, 146, 331,335.Google Scholar
2. Kokubo, T., J. Non-Crystal. Sol., 120, 138 (1990).Google Scholar
3. Ohtsuki, C., Kokubo, T., and Yamamuro, T., J. Non-Crystal. Sol., 143, 84 (1992).Google Scholar
4. Klein, C. P. A. T., De, J. M. A. Blieck-Hogerworst, Wolke, J. G. C., De Groot, K., Biomaterials, 11, 509 (1990).Google Scholar
5. Jarcho, M., Bolen, C. H., Thomas, M. B., Babock, J., Kay, J. F., and Doremus, R. H., J. Mat. Sci., 11, 2027 (1976).Google Scholar
6. Asada, M., Miura, Y., Osaka, A., Oukami, K., and Nakamura, S., J. Mat. Sci., 23, 3202 (1988).Google Scholar
7. Ebrahimpour, E., Johnson, M., Richardson, C. F., and Nancollas, G. H., J. Coll. Int. Sci., 159, 158 (1993).Google Scholar
8. Zhou, J., Zhang, X., Chen, J., Zeng, S., and De Groot, K., J. Mat. Sci.: Mat. in Med., 4, 83 (1993).Google Scholar
9. Lazic, S., J. Cryst. Growth, 147, 147 (1995).Google Scholar
10. Tas, A. C., Korkusuz, F., Timucin, M., and Akkas, N., J. Mat. Sci.: Mat. in Med., 8, 91 (1997).Google Scholar
11. Madsen, H. E. L. and Thodvadarson, G., J. Cryst. Growth, 66, 369 (1984).Google Scholar
12. Tas, A. C., "Biomimetic Synthesis of Carbonated Calcium Hydroxyapatite Powders at 37°C with Urea- or Enzyme Urease-containing Synthetic Body Fluids," Patent Pending, No: 99/00037, Turkish Patent Institute, Ankara, Turkey, January 11, 1999.Google Scholar
13. Simpson, R. E., Habeger, C., Rabinovich, A. and Adair, J. H., J. Am. Ceram. Soc., 81, 1377 (1998).Google Scholar
14. Kivrak, N. and Tas, A. C., J Am. Ceram. Soc., 81, 2245 (1998).Google Scholar
15. Tas, A. C., "Synthesis of Biomimetic Ca-Hydroxyapatite Powders at 37°C in Synthetic Body Fluids," Biomaterials (UK), In Print (BM216/98; November 1999).Google Scholar