Skip to main content Accessibility help

Bio-inspired Self-Assembly of Micro and Nano-Structures for Sensing and Electronic Applications

  • H. McNally (a1), S. W. Lee (a1), D. Guo (a1), M. Pingle (a2), D. Bergstrom (a2) and R. Bashir (a1) (a3)...


Bio-inspired assembly, through the use of bio-molecules such as DNA and proteins, will play a critical role in the advancement of novel sensing techniques and for the realization of heterogeneous integration of materials. For many of these applications, such as antibody-based biosensor and the study of controlled cell growth, DNA and protein patterning techniques are crucial. We will present an update of our work on protein patterning techniques using microelectronic fabrication, DNA hybridization and biotin-streptavidin pairing. To show its application in biological inspired self-assembly, this technique was used successfully in the self-assembly of 20 nm streptavidin conjugated gold particles. In addition, the integration of nano-and micro-scale heterogeneous materials is very important for novel material synthesis and electro-optic applications. We will present an update on our work to assemble silicon electronic devices using DNA/charged molecules and electric fields. Devices are fabricated, released, charged with molecules, and subsequently manipulated in electric fields. The techniques described can be used to integrate the hybrid devices such as nano- or micro-scale resistors, PN diodes, and MOSFETs on silicon or other substrates such as glass, plastic, etc.



Hide All
1. Niemeyer, C.M., Ceyhan, B., Gao, S., Chi, L., Peschel, S., and Simon, U., Colloid Polymer Science, 279, 68, (2001).
2. Edelstein, R.L., Tamanaha, C.R., Sheehan, P.E., Mille, M.M., Baselt, D.R., Whitman, L.J. and Colton, R.L., Biosensors & Bioelectronics, 14, 10, (2000).
3. Andres, R.P., Datta, S., Janes, D.B., Kubiak, C.P., and Reifenberger, R., in The Handbook of Nanostructured Materials and Nano-technology, (Academic Press, 1998) p. 10.
4. Lee, S.W., McNally, H.A., Guo, D., Pingle, M., Bergstrom, D.E., and Bashir, R., Langmuir; 18 (8), 33833386 (2002).
5. Yeh, H.J., and Smith, J.S., IEEE Photonics Technology Letters, 6 (6), 706 (1994).
6. Prohofsky, E., Statistical mechanics and stability of macromolecules: application to bond disruption, base pair separation, melting, and drug dissociation of the DNA double helix, (Cambridge University Press, New York, NY, 1995) p. 34.
7. Methods in Enzymology, edited by Wilcheck, M. and Bayer, E.A., (Academic Press, NewYork, NY, 1990) Vol. 184, p. 3.
8. Ulman, A., Chem. Rev., 96 (4), 15331554 (1996).
9. Pohl, H. A., Dielectrophoresis, (Cambridge University Press, Cambridge, UK, 1978) p52.
10. Ramos, A., Morgan, H., Green, N. G. and Castellanos, A., Journal of Physics D, 31, 23382353, (1998).
11. Ramos, A., Morgan, H., Green, N. G., and Castellanos, A., Journal of Electrostatics, 47, 7181, 1999.
12. Nebergall, W. H., Schmidt, F. C., Holtzclaw, H.F., General Chemistry, 5th Ed., (D.C. Heath and Company, Lexington, MA, 1976) p. 143.
13. McNally, H., Pingle, M., Lee, S.W., Guo, D., Bergstrom, D., Bashir, R., in Nanopatterning: from Ultralarge-scale Integration to Biotechnology, edited by Merhari, L., Gonsalves, K.E., Dobisz, E.A., Angelopoulos, M., Herr, D., (Mater. Res. Soc. Proc. 705, Pittsburgh, PA, 2002) pp. 177185.
14. Mirkin, C.A. and Taton, T.A., Nature 405, 626627, (2000).
15. Demers, L.M., Mirkin, C.A., Mucic, R.C., Reynolds, R.A., Letsinger, R.L., Elghanian, R., and Viswanadham, G., Analytical Chemistry, 72 (22), 55355541 (2000).
16. Bashir, R., Lee, S.W., Guo, D., Pingle, M., Bergstrom, D., McNally, H., and Janes, D., in Nonlithographic and Lithographic Methods of Nanofabrication: From Ultralarge-Scale Integration to Photonics to Molecular Electronics, edited by Merhari, L., Rogers, J.A., Karim, A., Norris, D.J., Xia, Y., (Mater. Res. Soc. Proc. 636, Pittsburgh, PA, 2001).
17. Lee, S.W., McNally, H., Bashir, R., Pingle, M., Bergstrom, D., accepted for publication (Mater. Res. Soc. Proc. 735, Pittsburgh, PA, 2003).
18. Mbindyo, J.K.N., Reiss, B.D., Martin, B.R., Keating, C.D., Natan, M.J. and Mallouk, T.E., Adv. Mater. 13 (4), 249, (2001).
19. White, Frank M., Viscous Fluid Flow, 2nd Ed., (McGraw Hill, Boston, MA. 1991) p. 67.


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed