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Biocompatibility of Polyurethane Urea Elastomers for Cardiac Tissue Engineering

  • A. Paredes-Puerto (a1) (a2), D. Dashti (a2), Y. Yeghiazarians, K.E. Healy (a2) (a3) and F. Hernández-Sánchez (a1)...

Abstract

Cardiac disease is the main cause of death in men and women in México and the U.S.A. When heart muscle suffers an injury, i.e. cardiac infarction, the tissue dies and is replaced by a fibrotic scar that does not allow for normal organ function. To alleviate scar tissue, the objective of this work was to investigate and synthesize polyurethane ureas from polycaprolactone diol, methylene bis(4-cyclohexilisocyanate), and butanediamine with different hard segment contents, characterize them, and prove their biocompatibility by seeding SCA-1+/CD45- cardiac progenitor cells obtained from mice cardiospheres. Ultimately, this work aims to explore how polyurethane urea elastomers can aid in therapeutic cardiac tissue regeneration.

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1. P. Instituto Nacional de Salud, Salud Pública de México 44(3), 226–282 (2002).
2. Lloyd-Jones, D., Adams, R., Brown, T., Carnethon, M., Dai, S., De Simone, G., Ferguson, T., Ford, E., Furie, K. and Gillespie, C., Circulation (2009).
3. May-Hernández, L., Hernández-Sánchez, F., Gomez-Ribelles, J. L. and Sabater-i Serra, R., Journal of Applied Polymer Science 119(4), 20932104 (2011).

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