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Biocompatibility of CAD/CAM ORMOCER polymer scaffold structures

  • A. Doraiswamy (a1), T. Patz (a1), R. Narayan (a1), B. Chichkov (a2), A. Ovsianikov (a2), R. Houbertz (a3), R. Modi (a4), R. Auyeung (a4) and D. B. Chrisey (a4)...

Abstract

A fresh approach with a novel process and a hybrid material is explored for developing designer 3-dimensional functional tissue scaffolds. The process of two photon-induced polymerization generally used for electronic and optical materials is introduced for developing biological scaffolds. Hybrid materials containing organic-inorganic units, ORMOCERs, fabricated with this process are tested for biocompatibility using various cell-types and compared with known standards such as polystyrene and ECM (Extracellular Matrix). Results show good adherence of different cells to these materials, and a growth rate comparable to bioactive materials. Structures with various surface topologies are developed and tested for preferential growth. The study is a first step towards developing bioactive and bioresorbable heterogeneous three-dimensional scaffolds.

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[1] Serbin, J. et al, Optics Letters, Vol. 28 No. 5 301 (2003)
[2] Serbin, J. et al, Optics Express, Vol. 12 No. 21 5222 (2004)
[3] Mauro, S. et al, Optics Letters, Vol. 22 No. 2 132 (1997)
[4] Hass, KH, Current Opinion in Solid State and Materials Science, 4 571580 (1999)

Biocompatibility of CAD/CAM ORMOCER polymer scaffold structures

  • A. Doraiswamy (a1), T. Patz (a1), R. Narayan (a1), B. Chichkov (a2), A. Ovsianikov (a2), R. Houbertz (a3), R. Modi (a4), R. Auyeung (a4) and D. B. Chrisey (a4)...

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