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Application of clay as a means of support to biomaterial with anti-inflammatory agents

  • M.L. Domínguez-Patiño (a1), M Chávez-Castillo (a2), A. Rodríguez-Martínez (a3), R.M. Melgoza Alemán (a1), E Jiménez-Ferrer (a4) and M. Herrera-Ruíz (a4)...

Abstract

In the last fifteen years, there have been significant changes in the production of medicines, mainly in the addition of new components to the formulation of solid dosage forms. The current trend of “back to nature” to lead to a healthier life has led those who are engaged in the pharmaceutical field to develop new formulations that allow the use of natural products of plant origin

For example, excipient ingredients, used as carriers for a drug's active ingredients, are now being used. These are incorporated into a drug in order to facilitate the drug's preparation, maintenance, or administration. The excipient is beneficial to the patient because it allows the drug to be easily administered and absorbed by the human body [3]

There is evidence that the clays have great potential for both absorption and adsorption due to its tiny particles. In addition, it has been reported that some clays have an effective antiseptic and healing ability [5–8]

In the present work, a clay called bentonite was tested as a support vehicle of an inflammatory agent derived from a Mexican native plant called Distictis buccinatoria, commonly named “Tonacaxóchitl”. Studies carried out by Rojas et al. have shown that the organic extract of this plant has important antibacterial, antifungal, cytotoxic and anti-inflammatory properties [9]

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2. Peppas, N., Langer, R., “New Challenges in Biomaterials”, Science, 263:17151720, (1994).
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4. Abraham, GA, Cuadrado, T. R. Biomaterials and cardiovascular devices. Fed Rev Argent Cardiol; 26 (4) :491–7 (1997).
5. May., Bennett R. H. & Hulbert, M. H. “Clay Microstructure.”; Published by D. Reidel Publishing Company. 161 pp. (1986).
6. Montoya, Doval, Bentonite., M. in: Mineral Resources of Spain. Coord. J. García Guinea and J. Martinez Frias. College Texts (C.S.I.C.) 15. pp 4569, (1990).
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8. Gardens, Galán E. “Clay” In: Mineral Resources of Spain. Coord. J. García Guinea and J. Martinez Frias. College Texts (C.S.I.C.) 15. pp 2325, (1990).
9. Gabriela, R. B. Ma; “Antibacterial, antifungal, and cytotoxic Activities of Distictis Buccinatoria Pharmaceutical Biology Vol 45, No. 4, pp. 289294 (2007).
10. Warner, T. D. and Mitchell, J. A. Cyclooxygenase : new forms, new inhibitors, and lessons from the clinic. FASEB J. 18: 790804 (2004).

Application of clay as a means of support to biomaterial with anti-inflammatory agents

  • M.L. Domínguez-Patiño (a1), M Chávez-Castillo (a2), A. Rodríguez-Martínez (a3), R.M. Melgoza Alemán (a1), E Jiménez-Ferrer (a4) and M. Herrera-Ruíz (a4)...

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