Skip to main content Accessibility help

Actin Nanotracks for Hybrid Nanodevices Based on Linear Protein Molecular Motors

  • G. S. Watson (a1), C. Cahill (a1), J. Blach (a1), S. Myhra (a1), Y. Alexeeva (a2), E.P. Ivanova (a2) and D. V. Nicolau (a2)...


Hybrid nano-devices based on linear protein molecular motors working on micro/nano-engineered surfaces that operate in a “cargo architecture”, i.e. motor functionalized nano-objects running on nano-tracks, offer more opportunities than the inverse “sliding architecture” because it fully uses the information regarding directionality which is encoded in tracks, i.e. actin filaments or microtubules. However, this architecture requires the development of techniques for nanolithography with actin filaments (or microtubules) based on molecular self-assembly on engineered surfaces. The present contribution reports on the progress we have made regarding the building of actin nanostructures that would preserve the inherent information over extended micro-sized areas.



Hide All
1. Suzuki, H., Oiwa, K., Yamada, A., Sakakibara, H., Nakayama, H., Mashiko, S. Jpn. J. Appl. Phys. 34:39373941 (1995).
2. Turner, D. C., Chang, C., Fang, K., Brandow, S. L., Murphy, D. B. Biophys. J. 69:27822789, (1995).
3. Suzuki, H., Yamada, A., Oiwa, K., Nakayama, H. and Mashiko, S.. 1997. Biophys. J. 72:1997-(2001).
4. Nicolau, D.V., Suzuki, H., Mashiko, S., Taguchi, T., Yoshikawa, S. Biophys. J, 77 (2), 9904499065, (1999).
5. Dennis, J. R., Howard, J., and Vogel, V.. Nanotechnology. 10:232236, (1999).
6. Mahanivong, C., Wright, J. P., Kekic, M., Pham, D. K., dos Remedios, C., Nicolau, D.V. Biomedical Microdevices 4(2): 111116; (2002).
7. Bunk, R., Klinth, J., Rosengren, J., Nicholls, I., Tagerud, S., Omling, P., Mansson, A., Montelius, L. Microelectronic Engineering 67–68 899904 (2003).
8. Hiratsuka, Y., Tada, T., Oiwa, K., Kanayama, T., Uyeda, T.Q. P. Biophys. J. 81 15551561 (2001).
9. Clemmens, J., Hess, H., Howard, J., Vogel, V. Langmuir; 19(5); 17381744 (2003).
10. Riveline, D., Ott, A., Julicher, F., Winkelmann, D. A., Cardoso, O., Lacapere, J. J., Magnusdottir, S., Viovy, J. L., Gorre-Talini, L. & Prost, J. Eur Biophys J. 27, 403–8 (1998).
11. Hess, H., Clemmens, J., Qin, D., Howard, J. & Vogel, V. Nano Letters 1, 235239, (2001).
12. Stracke, R., Bohm, K. J., Burgold, J., Schacht, H., Unger, E. Nanotechnology. 11:5256, (2000).
13. Hess, H.; Howard, J.; Vogel, V. Nano Lett. 2(10); 11131115 (2002).
14. Hess, H.; Clemmens, J.; Howard, J.; Vogel, V. Nano Lett. 2(2); 113116 (2002).
15. Nicolau, D. V. Jr.; Nicolau, D. V. In Biomedical Applications of Micro- and Nanoengineering. SPIE Proc. 4937, 219225, (2002).
16. Yanagida, T., Nakase, M., Nishiyama, K., Oosawa, F. Nature 307, 5860, (1984).
17. Spudich, J. A., Kron, S. J., Sheetz, M. P. Nature, 315, 584586, (1985).
18. Kabsh, W., Mannherz, H.G., Such, D., Pai, E. F., Holmes, K.C. Nature 347, 3744 (1990).
19. Pollard, T.D. Annu. Rev. Biochem. 55, 9871035 (1986).
20. Xu, J., Schwarz, W. H., Kas, J. A., Stossel, T. P., Janmey, P. A., Pollard, T. D. Biophys. J 74, 27312740 (1998).
21. Higgs, H. N. Pollard, T. D. Annu. Rev. Biochem. 70: 649–76 (2001).
22. Janmey, P. A., Tang, J.X., Schmidt, C.F.
23. Chik, J. K., Lindberg, U., Schutt, C. E. J Mol Biol 263. 607 (1996). From Protein Data Bank: Berman, H.M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T.N., Weissig, H., Shindyalov, I.N., Bourne, P.E. Nucleic Acids Research, 28,. 235-242 (2000).
24. Kojima, H., Ishijima, A., and Yanagida, T.. Proc Natl Acad Sci USA. 91:12962–6 (1994).
25. Huxley, H. E., Stewart, A., Sosa, H., and Irving, T.. Biophys. J. 67:2411–21 (1994).
26. Higuchi, H., Yanagida, T., and Goldman, Y. E.. Biophys. J. 69:1000–10 (1995).
27. Wakabayashi, K., Sugimoto, Y., Tanaka, H., Ueno, Y., Takezawa, Y., Amemiya, Y.. Biophys. J 67, 24222435. (1994).
28. Wright, J.P., Pham, D.K., Mahanivong, C., Kekic, M., dos Remedios, C.G., Nicolau, D.V. Biomedical Microdevices 4(3): 205211; (2002).
29. Angelini, T.E., Liang, H., Wriggers, W., Wong, G.C.L.. Proc. Natl. Acad. Sci. USA 100, (2003).
30. Shi, D, Somlyo, A V, Somlyo, A P, Shao, Z, J. Microsc. 201: 377382 (2001).
31. RF, Considine, RA, Hayes, RG, Horn, Langmuir, 15: 16571659 (1999).
32. St-Onge, D, Gicquaud, C, Cell. Biol. 67: 297300 (1989).


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed