Skip to main content Accessibility help
×
Home

Modified Microparticles of Calcium Alginate Gel for Controlled Release of Anesthetics

Published online by Cambridge University Press:  01 February 2011


Erkesh E. Batyrbekov
Affiliation:
erkeshbatyrbekov@mail.ru, Institute of Chemical Sciences, Polymer, 106 Valikhanov Street, Almaty, 050010, Kazakhstan, 7-3272-912457
Turar N. Akylbekova
Affiliation:
Institute of Chemical Sciences, 106 Valikhanov Street, Almaty, 050010, Kazakhstan
Rinat M. Iskakov
Affiliation:
Institute of Chemical Scinces, 106 Vakikhanov Street, Almaty, 050010, Kazakhstan
Corresponding
E-mail address:

Abstract

The aim of this work is the development of controlled delivery system immobilized by local anesthetics on the basis of modified microparticles of calcium alginate gels. The kazkain, rikhlokain, lidokain and novokain were used as local anesthetics. Modified microparticles were obtained by syringed dropwise a solution of ansthetics in sodium alginate into solution of polymers such as chitosan or polyethyleneimine in calcium chloride. The obtained modified alginate microparticles were contained immobilized anesthetics in core of particles and a surface layer of polymer. Effects of polymer concentration and exposure duration on the thickness of polymer coating were determined. The release of anesthetics from the modified alginate gel particles into a physiological solution with different thickness of coating were studied. All the release data show the typical pattern for a matrix controlled mechanism. The cumulative amount of drug released from alginate gels was linearly related to the square root of the time and the release rate decreased this time. The process is controlled by the diffusion of anesthetics through the polymeric coating. The data shown a possibility of the regulation of the rate of anesthetics release from the modified alginate particles by way of alternation of thickness of the polymer coating. The anesthetic effect of the alginate microparticles containing drugs was tested on rats by method “tail flick” according two criteria: full analgesia – the absence of reaction on pain and sufficient analgesia – exceeding of pain threshold sensibility two and more times. Medical-biological tests show that the duration of anesthetic activity for the drug-containing alginate beads increases at 5-8 times in comparison of free drugs.


Type
Research Article
Copyright
Copyright © Materials Research Society 2008

Access options

Get access to the full version of this content by using one of the access options below.

References

1. Gebelain, C.G., and Carraher, C.E. Bioactive Polymeric Systems. An Overview. Plenum, N.Y., 1985.CrossRefGoogle Scholar
2. Hsien, D.S. Controlled Release Systems: Fabrication Technology. CRC Press, Boca Raton, Florida, 1988, p.196.Google Scholar
3. Zhubanov, B.A., Batyrbekov, E.O. and Iskakov, R.M. Polymeric materials of medicinal activity. Komplex, Almaty, 2000. 220 p.Google Scholar
4. Sime, W.J.. Alginates. Food Gel, in Harris, P. (ed.), Elsevier, Amsterdam. 1989, p.53.Google Scholar
5. Dumitriu, S. Polymeric Biomaterials. Second Edition. Marcel Dekker Inc., N.Y., 2002, p.1.Google Scholar
6. Tonnesen, H.H. and Karlsen, J. Drug Dev. Ind. Pharm. 28:621 (2002).CrossRefGoogle Scholar
7. Braccini, I. and Perez, S. Biomacromolecules 54:342 (2001).Google Scholar
8. Acarturk, F. and Takka, S. J. Microencapsulation 16:291 (1999).CrossRefGoogle Scholar
9. Shiraishi, S., Imai, T. and Otagiri, M. Biol. Pharm. Bull. 16:1164 (1993).CrossRefGoogle Scholar
10. Aslasni, P. and Kennedy, R. J. Microencapsulation 13:601 (1999).CrossRefGoogle Scholar
11. Batyrbekov, E.O., Iskakov, R.M. and Zhubanov, B.A. Architecture and Application of Biomaterials and Biomolecular Materials. Materials Research Society, Warrendale, 2004, p. 413.Google Scholar
12. Iskakov, R., Batyrbekov, E.O., Zhubanov, B.A., Yu, V.K., Praliev, K.D. and Berlin, D.K. Euras. ChemTech. Journ. 4:293 (2002).CrossRefGoogle Scholar
13. Murata, Y., Toniwa, S., Miyamoto, E. and Kawashima, S. Eur. J. Pharm. Biopharm. 48:49 (1999).CrossRefGoogle Scholar
14. Thu, B., Bruheim, P., Espevik, T., Smidsrod, O., Soon-Shiong, P. and Skjak-Bræk, G. Biomaterials 17:1031 (1996).CrossRefGoogle Scholar
15. Iskakov, R., Kikuchi, A. and Okano, T. Journ. Control. Rel. 80:57 (2002).CrossRefGoogle Scholar
16. Kikuchi, A., Kawabuchi, M., Sugihara, M., Sakurai, Y. and Okano, T. Journ. Control. Rel. 47:21 (1997).CrossRefGoogle Scholar
17. Lee, K.Y., Park, W.H. and Ha, W.S. Journ. Appl. Polym. Sci. 63:425 (1997).3.0.CO;2-T>CrossRefGoogle Scholar

Full text views

Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.

Total number of HTML views: 0
Total number of PDF views: 5 *
View data table for this chart

* Views captured on Cambridge Core between September 2016 - 1st December 2020. This data will be updated every 24 hours.

Hostname: page-component-6d4bddd689-kpd2z Total loading time: 0.473 Render date: 2020-12-01T16:33:45.960Z Query parameters: { "hasAccess": "0", "openAccess": "0", "isLogged": "0", "lang": "en" } Feature Flags last update: Tue Dec 01 2020 15:57:50 GMT+0000 (Coordinated Universal Time) Feature Flags: { "metrics": true, "metricsAbstractViews": false, "peerReview": true, "crossMark": true, "comments": true, "relatedCommentaries": true, "subject": true, "clr": false, "languageSwitch": true }

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Modified Microparticles of Calcium Alginate Gel for Controlled Release of Anesthetics
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Modified Microparticles of Calcium Alginate Gel for Controlled Release of Anesthetics
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Modified Microparticles of Calcium Alginate Gel for Controlled Release of Anesthetics
Available formats
×
×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *