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Cell viability study of green synthesized CdTe/CdSe quantum dots against osteosarcoma cell line for improved therapeutic action

Published online by Cambridge University Press:  29 January 2019

Ncapayi Vuyelwa  and
Oluwatobi S. Oluwafemi
Ncapayi Vuyelwa
Affiliation:
Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus, P.O. Box 17011, Doornfontein, 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, 2028, South Africa
Oluwatobi S. Oluwafemi*
Affiliation:
Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus, P.O. Box 17011, Doornfontein, 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, 2028, South Africa
*
Address all correspondence to Oluwatobi S. Oluwafemi at oluwafemi.oluwatobi@gmail.com
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Abstract

LM-8 is a murine osteosarcoma cell line associated with bone tumor in young adult and children. It contains the nuclear factor-κB which make this cell high resistance to irradiation thus limiting its treatment only to chemotherapy and surgery which has become a source of concerned for cancer therapy. In addressing this problem, we herein report the synthesis of CdTe/CdSe core/shell quantum dots (QDs) via a simple, reproducible method and its cytotoxic action against the LM-8 cell line. The cell viability study shows that the as-synthesized QDs are toxic to the LM-8 cell line in a concentration- and time-dependent manner.

Type
Research Letters
Information
MRS Communications , Volume 9 , Issue 1 , March 2019 , pp. 340 - 343
Copyright
Copyright © Materials Research Society 2019 

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