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Biocompatibility of a novel heat-treated and ceramic-coated magnesium alloy (Mg–1.2Zn–0.5Ca–0.5Mn) for resorbable skeletal fixation devices

Published online by Cambridge University Press:  10 August 2020

Agnieszka Chmielewska ,
Taylor MacDonald ,
Hamdy Ibrahim ,
Tim McManus ,
Jan Lammel Lindemann Open the ORCID record for Jan Lammel Lindemann [Opens in a new window] ,
Patrick Smith ,
Lihan Rong ,
Alan Luo ,
Rigoberto Advincula  and
Wojciech Swieszkowski
...Show all authors
Agnieszka Chmielewska
Affiliation:
Department of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH43210, USA Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw02-507, Poland
Taylor MacDonald
Affiliation:
Department of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH43210, USA
Hamdy Ibrahim
Affiliation:
Department of Mechanical Engineering, University of Tennessee – Chattanooga, Chattanooga, TN37403, USA
Tim McManus
Affiliation:
Department of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH43210, USA
Jan Lammel Lindemann
Affiliation:
Department of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH43210, USA Escuela de Ingenieria y Ciencias, Tecnologico de Monterrey, Monterrey, NL64849, Mexico Laboratorio Nacional de Manufactura Aditiva y Digital (MADiT), Apodaca, NL66629, Mexico
Patrick Smith
Affiliation:
Department of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH43210, USA
Lihan Rong
Affiliation:
Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH44106, USA
Alan Luo
Affiliation:
Department of Materials Science and Engineering, The Ohio State University, Columbus, OH43210, USA
Rigoberto Advincula
Affiliation:
Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH44106, USA
Wojciech Swieszkowski
Affiliation:
Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw02-507, Poland
Mohammad Elahinia
Affiliation:
Department of Mechanical, Industrial and Manufacturing Engineering, University of Toledo, Toledo, OH43606, USA
David Dean*
Affiliation:
Department of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH43210, USA Department of Materials Science and Engineering, The Ohio State University, Columbus, OH43210, USA
*
Address all correspondence to David Dean at David.Dean@osumc.edu
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Abstract

Our recent exploration into the use of biodegradable metals and surface treatments resulting in sufficient strength for skeletal reconstruction applications has led to the need to test these devices’ cytotoxicity. More specifically, our group has developed a resorbable magnesium alloy, Mg–1.2Zn–0.5Ca–0.5Mn, that can be strengthened by heat treatment and coated with a ceramic layer offering time-certain resorption of a medical device. This in vitro study shows that these treatments do not result in cytotoxicity. Both heat-treated (HT) and HT + ceramic-coated (sol–gel) coupons demonstrated more than 70% viability. Thus, these processing steps are likely to be useful in producing biocompatible, resorbable implants that incorporate our Mg–1.2Zn–0.5Ca–0.5Mn alloy.

Type
Research Letters
Information
MRS Communications , Volume 10 , Issue 3 , September 2020 , pp. 467 - 474
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Copyright
Copyright © Materials Research Society, 2020

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Footnotes

*

This author was an editor of this journal during the review and decision stage. For the MRC policy on review and publication of manuscripts authored by editors, please refer to http://www.mrs.org/editor-manuscripts/.

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